Cargando…

Molecular basis for histone N-terminal methylation by NRMT1

NRMT1 is an N-terminal methyltransferase that methylates histone CENP-A as well as nonhistone substrates. Here, we report the crystal structure of human NRMT1 bound to CENP-A peptide at 1.3 Å. NRMT1 adopts a core methyltransferase fold that resembles DOT1L and PRMT but not SET domain family histone...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Ruoxi, Yue, Yuan, Zheng, Xiangdong, Li, Haitao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2015
Materias:	Research Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691888/ https://www.ncbi.nlm.nih.gov/pubmed/26543159 http://dx.doi.org/10.1101/gad.270926.115

Ejemplares similares

NRMT is an α-N-methyltransferase that methylates RCC1 and Retinoblastoma Protein
por: Tooley, Christine E. Schaner, et al.
Publicado: (2010)

Loss of the N-terminal methyltransferase NRMT1 increases sensitivity to DNA damage and promotes mammary oncogenesis
por: Bonsignore, Lindsay A., et al.
Publicado: (2015)

α-amino trimethylation of CENP-A by NRMT is required for full recruitment of the centromere
por: Sathyan, Kizhakke M., et al.
Publicado: (2017)

Molecular basis for oncohistone H3 recognition by SETD2 methyltransferase
por: Yang, Shuang, et al.
Publicado: (2016)

Structural basis for substrate recognition by the human N-terminal methyltransferase 1
por: Dong, Cheng, et al.
Publicado: (2015)

Knockdown of NRMT enhances sensitivity of retinoblastoma cells to cisplatin through upregulation of the CENPA/Myc/Bcl2 axis
por: Li, Zhongrui, et al.
Publicado: (2022)

Molecular basis for histidine N3-specific methylation of actin H73 by SETD3
por: Zheng, Yihui, et al.
Publicado: (2020)

Molecular basis underlying histone H3 lysine–arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1
por: Su, Xiaonan, et al.
Publicado: (2014)

Age-related neurodegeneration and cognitive impairments of NRMT1 knockout mice are preceded by misregulation of RB and abnormal neural stem cell development
por: Catlin, James P., et al.
Publicado: (2021)

Molecular basis for the methylation specificity of ATXR5 for histone H3
por: Bergamin, Elisa, et al.
Publicado: (2017)

Structure of the human histone chaperone FACT Spt16 N-terminal domain
por: Marcianò, G., et al.
Publicado: (2016)

Molecular basis for bipartite recognition of histone H3 by the PZP domain of PHF14
por: Zheng, Shuangping, et al.
Publicado: (2021)

The structural basis for the oligomerization of the N-terminal domain of SATB1
por: Wang, Zheng, et al.
Publicado: (2012)

Molecular basis for hierarchical histone de-β-hydroxybutyrylation by SIRT3
por: Zhang, Xingrun, et al.
Publicado: (2019)

Molecular basis for protein histidine N1-specific methylation of the “His-x-His” motifs by METTL9
por: Zhao, Wentao, et al.
Publicado: (2023)

Molecular basis for METTL9-mediated N1-histidine methylation
por: Wang, Xiaoyang, et al.
Publicado: (2023)

Molecular basis for histone H3 “K4me3-K9me3/2” methylation pattern readout by Spindlin1
por: Zhao, Fan, et al.
Publicado: (2021)

Molecular basis for N-terminal alpha-synuclein acetylation by human NatB
por: Deng, Sunbin, et al.
Publicado: (2020)

Molecular basis for the role of oncogenic histone mutations in modulating H3K36 methylation
por: Zhang, Yinglu, et al.
Publicado: (2017)

N-alpha-terminal Acetylation of Histone H4 Regulates Arginine Methylation and Ribosomal DNA Silencing
por: Schiza, Vassia, et al.
Publicado: (2013)

Histone H3 N-terminal mimicry drives a novel network of methyl-effector interactions
por: Chen, Jianji, et al.
Publicado: (2021)

Molecular basis for N-terminal acetylation by human NatE and its modulation by HYPK
por: Deng, Sunbin, et al.
Publicado: (2020)

Structural basis for the recognition of methylated histone H3 by the Arabidopsis LHP1 chromodomain
por: Liu, Yanli, et al.
Publicado: (2022)

4-N,N-Dimethylaminopyridine Promoted Selective Oxidation of Methyl Aromatics with Molecular Oxygen
por: Zhang, Zhan, et al.
Publicado: (2012)

Structural basis of recognition and destabilization of the histone H2B ubiquitinated nucleosome by the DOT1L histone H3 Lys79 methyltransferase
por: Jang, Seongmin, et al.
Publicado: (2019)

A Terminal Iron Nitrilimine Complex: Accessing the Terminal Nitride through Diazo N−N Bond Cleavage
por: Aghazada, Sadig, et al.
Publicado: (2019)

Contribution of histone N-terminal tails to the structure and stability of nucleosomes()()
por: Iwasaki, Wakana, et al.
Publicado: (2013)

Structural basis for the Rad6 activation by the Bre1 N-terminal domain
por: Shi, Meng, et al.
Publicado: (2023)

Histone deacetylase 6 structure and molecular basis of catalysis and inhibition
por: Hai, Yang, et al.
Publicado: (2016)

Small RNAs guide histone methylation in Arabidopsis embryos
por: Parent, Jean-Sébastien, et al.
Publicado: (2021)

Extended string-like binding of the phosphorylated HP1α N-terminal tail to the lysine 9-methylated histone H3 tail
por: Shimojo, Hideaki, et al.
Publicado: (2016)

Molecular Basis for Coordinating Transcription Termination with Noncoding RNA Degradation
por: Tudek, Agnieszka, et al.
Publicado: (2014)

Histone Methylation Restrains the Expression of Subtype-Specific Genes during Terminal Neuronal Differentiation in Caenorhabditis elegans
por: Zheng, Chaogu, et al.
Publicado: (2013)

Corrigendum to: Contribution of histone N‐terminal tails to the structure and stability of nucleosomes
por: Iwasaki, Wakana, et al.
Publicado: (2018)

Histone N-alpha terminal modifications: genome regulation at the tip of the tail
por: Demetriadou, Christina, et al.
Publicado: (2020)

Rtt109 slows replication speed by histone N-terminal acetylation
por: Frenkel, Nelly, et al.
Publicado: (2021)

Domain Metastability: A Molecular Basis for Immunoglobulin Deposition?
por: Sonnen, Andreas F.-P., et al.
Publicado: (2010)

The Molecular Basis of the Interaction of Cyclophilin A with α‐Synuclein
por: Favretto, Filippo, et al.
Publicado: (2020)

Molecular basis for the inhibition of the methyl-lysine binding function of 53BP1 by TIRR
por: Wang, Jiaxu, et al.
Publicado: (2018)

Intermolecular hydrogen bonding in N-methyl-N′-(pyridin-2-yl)benzene-1,2-diamine
por: Collis, Gavin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_fg1al8gpqjvu260hvj5gmi88i6