NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition

The mechanistic target of rapamycin (mTOR) is a central cell growth controller and forms two distinct complexes: mTORC1 and mTORC2. mTORC1 integrates a wide range of upstream signals, both positive and negative, to regulate cell growth. Although mTORC1 activation by positive signals, such as growth...

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Detalles Bibliográficos
Autores principales: Yuan, Hai-Xin, Wang, Zhen, Yu, Fa-Xing, Li, Fulong, Russell, Ryan C., Jewell, Jenna L., Guan, Kun-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691891/
https://www.ncbi.nlm.nih.gov/pubmed/26588989
http://dx.doi.org/10.1101/gad.265116.115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691891/
https://www.ncbi.nlm.nih.gov/pubmed/26588989
http://dx.doi.org/10.1101/gad.265116.115

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