High telomerase is a hallmark of undifferentiated spermatogonia and is required for maintenance of male germline stem cells

Telomerase inactivation causes loss of the male germline in worms, fish, and mice, indicating a conserved dependence on telomere maintenance in this cell lineage. Here, using telomerase reverse transcriptase (Tert) reporter mice, we found that very high telomerase expression is a hallmark of undiffe...

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Detalles Bibliográficos
Autores principales: Pech, Matthew F., Garbuzov, Alina, Hasegawa, Kazuteru, Sukhwani, Meena, Zhang, Ruixuan J., Benayoun, Bérénice A., Brockman, Stephanie A., Lin, Shengda, Brunet, Anne, Orwig, Kyle E., Artandi, Steven E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691947/
https://www.ncbi.nlm.nih.gov/pubmed/26584619
http://dx.doi.org/10.1101/gad.271783.115

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