Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry-sensitive shifts in target gene networks

Elf5 is a transcription factor with pivotal roles in the trophoblast compartment, where it reinforces a trophoblast stem cell (TSC)-specific transcriptional circuit. However, Elf5 is also present in differentiating trophoblast cells that have ceased to express other TSC genes such as Cdx2 and Eomes....

Descripción completa

Detalles Bibliográficos
Autores principales: Latos, Paulina A., Sienerth, Arnold R., Murray, Alexander, Senner, Claire E., Muto, Masanaga, Ikawa, Masahito, Oxley, David, Burge, Sarah, Cox, Brian J., Hemberger, Myriam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691948/
https://www.ncbi.nlm.nih.gov/pubmed/26584622
http://dx.doi.org/10.1101/gad.268821.115

Ejemplares similares

Ejemplares similares