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Unliganded EphA3 dimerization promoted by the SAM domain

The erythropoietin-producing hepatocellular carcinoma A3 (EphA3) receptor tyrosine kinase (RTK) regulates morphogenesis during development and is overexpressed and mutated in a variety of cancers. EphA3 activation is believed to follow a ‘seeding mechanism’ model, in which ligand binding to the mono...

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Detalles Bibliográficos
Autores principales:	Singh, Deo R., Cao, QingQing, King, Christopher, Salotto, Matt, Ahmed, Fozia, Zhou, Xiang Yang, Pasquale, Elena B., Hristova, Kalina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2015
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692061/ https://www.ncbi.nlm.nih.gov/pubmed/26232493 http://dx.doi.org/10.1042/BJ20150433

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