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Solution NMR characterization of chemokine CXCL8/IL-8 monomer and dimer binding to glycosaminoglycans: structural plasticity mediates differential binding interactions

Chemokine CXCL8/interleukin-8 (IL-8) plays a crucial role in directing neutrophils and oligodendrocytes to combat infection/injury and tumour cells in metastasis development. CXCL8 exists as monomers and dimers and interaction of both forms with glycosaminoglycans (GAGs) mediate these diverse cellul...

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Detalles Bibliográficos
Autores principales:	Joseph, Prem Raj B., Mosier, Philip D., Desai, Umesh R., Rajarathnam, Krishna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2015
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692082/ https://www.ncbi.nlm.nih.gov/pubmed/26371375 http://dx.doi.org/10.1042/BJ20150059

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