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Substrate Oxidation by Indoleamine 2,3-Dioxygenase: EVIDENCE FOR A COMMON REACTION MECHANISM

The kynurenine pathway is the major route of l-tryptophan (l-Trp) catabolism in biology, leading ultimately to the formation of NAD(+). The initial and rate-limiting step of the kynurenine pathway involves oxidation of l-Trp to N-formylkynurenine. This is an O(2)-dependent process and catalyzed by i...

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Detalles Bibliográficos
Autores principales:	Booth, Elizabeth S., Basran, Jaswir, Lee, Michael, Handa, Sandeep, Raven, Emma L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2015
Materias:	Enzymology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692220/ https://www.ncbi.nlm.nih.gov/pubmed/26511316 http://dx.doi.org/10.1074/jbc.M115.695684

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