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HIF-2α-mediated induction of pulmonary thrombospondin-1 contributes to hypoxia-driven vascular remodelling and vasoconstriction

AIMS: Hypoxic conditions stimulate pulmonary vasoconstriction and vascular remodelling, both pathognomonic changes in pulmonary arterial hypertension (PAH). The secreted protein thrombospondin-1 (TSP1) is involved in the maintenance of lung homeostasis. New work identified a role for TSP1 in promoti...

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Detalles Bibliográficos
Autores principales:	Labrousse-Arias, David, Castillo-González, Raquel, Rogers, Natasha M., Torres-Capelli, Mar, Barreira, Bianca, Aragonés, Julián, Cogolludo, Ángel, Isenberg, Jeffrey S., Calzada, María J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	ORIGINAL ARTICLES
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692290/ https://www.ncbi.nlm.nih.gov/pubmed/26503986 http://dx.doi.org/10.1093/cvr/cvv243

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