KRAS Genotype Correlates with Proteasome Inhibitor Ixazomib Activity in Preclinical In Vivo Models of Colon and Non-Small Cell Lung Cancer: Potential Role of Tumor Metabolism

In non-clinical studies, the proteasome inhibitor ixazomib inhibits cell growth in a broad panel of solid tumor cell lines in vitro. In contrast, antitumor activity in xenograft tumors is model-dependent, with some solid tumors showing no response to ixazomib. In this study we examined factors respo...

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Detalles Bibliográficos
Autores principales: Chattopadhyay, Nibedita, Berger, Allison J., Koenig, Erik, Bannerman, Bret, Garnsey, James, Bernard, Hugues, Hales, Paul, Maldonado Lopez, Angel, Yang, Yu, Donelan, Jill, Jordan, Kristen, Tirrell, Stephen, Stringer, Bradley, Xia, Cindy, Hather, Greg, Galvin, Katherine, Manfredi, Mark, Rhodes, Nelson, Amidon, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692403/
https://www.ncbi.nlm.nih.gov/pubmed/26709701
http://dx.doi.org/10.1371/journal.pone.0144825

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692403/
https://www.ncbi.nlm.nih.gov/pubmed/26709701
http://dx.doi.org/10.1371/journal.pone.0144825

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