Identification and Validation of Novel Hedgehog-Responsive Enhancers Predicted by Computational Analysis of Ci/Gli Binding Site Density

The Hedgehog (Hh) signaling pathway directs a multitude of cellular responses during embryogenesis and adult tissue homeostasis. Stimulation of the pathway results in activation of Hh target genes by the transcription factor Ci/Gli, which binds to specific motifs in genomic enhancers. In Drosophila,...

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Detalles Bibliográficos
Autores principales: Gurdziel, Katherine, Lorberbaum, David S., Udager, Aaron M., Song, Jane Y., Richards, Neil, Parker, David S., Johnson, Lisa A., Allen, Benjamin L., Barolo, Scott, Gumucio, Deborah L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692483/
https://www.ncbi.nlm.nih.gov/pubmed/26710299
http://dx.doi.org/10.1371/journal.pone.0145225

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