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R4496C RyR2 mutation impairs atrial and ventricular contractility

Ryanodine receptor (RyR2) is the major Ca(2+) channel of the cardiac sarcoplasmic reticulum (SR) and plays a crucial role in the generation of myocardial force. Changes in RyR2 gating properties and resulting increases in its open probability (P(o)) are associated with Ca(2+) leakage from the SR and...

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Detalles Bibliográficos
Autores principales:	Ferrantini, Cecilia, Coppini, Raffaele, Scellini, Beatrice, Ferrara, Claudia, Pioner, Josè Manuel, Mazzoni, Luca, Priori, Silvia, Cerbai, Elisabetta, Tesi, Chiara, Poggesi, Corrado
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2016
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692489/ https://www.ncbi.nlm.nih.gov/pubmed/26666913 http://dx.doi.org/10.1085/jgp.201511450

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