The Controversy, Challenges, and Potential Benefits of Putative Female Germline Stem Cells Research in Mammals

The conventional view is that female mammals lose their ability to generate new germ cells after birth. However, in recent years, researchers have successfully isolated and cultured a type of germ cell from postnatal ovaries in a variety of mammalian species that have the abilities of self-prolifera...

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Autores principales: Pan, Zezheng, Sun, Mengli, Liang, Xia, Li, Jia, Zhou, Fangyue, Zhong, Zhisheng, Zheng, Yuehui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693009/
https://www.ncbi.nlm.nih.gov/pubmed/26788065
http://dx.doi.org/10.1155/2016/1728278
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author Pan, Zezheng
Sun, Mengli
Liang, Xia
Li, Jia
Zhou, Fangyue
Zhong, Zhisheng
Zheng, Yuehui
author_facet Pan, Zezheng
Sun, Mengli
Liang, Xia
Li, Jia
Zhou, Fangyue
Zhong, Zhisheng
Zheng, Yuehui
author_sort Pan, Zezheng
collection PubMed
description The conventional view is that female mammals lose their ability to generate new germ cells after birth. However, in recent years, researchers have successfully isolated and cultured a type of germ cell from postnatal ovaries in a variety of mammalian species that have the abilities of self-proliferation and differentiation into oocytes, and this finding indicates that putative germline stem cells maybe exist in the postnatal mammalian ovaries. Herein, we review the research history and discovery of putative female germline stem cells, the concept that putative germline stem cells exist in the postnatal mammalian ovary, and the research progress, challenge, and application of putative germline stem cells in recent years.
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spelling pubmed-46930092016-01-19 The Controversy, Challenges, and Potential Benefits of Putative Female Germline Stem Cells Research in Mammals Pan, Zezheng Sun, Mengli Liang, Xia Li, Jia Zhou, Fangyue Zhong, Zhisheng Zheng, Yuehui Stem Cells Int Review Article The conventional view is that female mammals lose their ability to generate new germ cells after birth. However, in recent years, researchers have successfully isolated and cultured a type of germ cell from postnatal ovaries in a variety of mammalian species that have the abilities of self-proliferation and differentiation into oocytes, and this finding indicates that putative germline stem cells maybe exist in the postnatal mammalian ovaries. Herein, we review the research history and discovery of putative female germline stem cells, the concept that putative germline stem cells exist in the postnatal mammalian ovary, and the research progress, challenge, and application of putative germline stem cells in recent years. Hindawi Publishing Corporation 2016 2015-12-15 /pmc/articles/PMC4693009/ /pubmed/26788065 http://dx.doi.org/10.1155/2016/1728278 Text en Copyright © 2016 Zezheng Pan et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Pan, Zezheng
Sun, Mengli
Liang, Xia
Li, Jia
Zhou, Fangyue
Zhong, Zhisheng
Zheng, Yuehui
The Controversy, Challenges, and Potential Benefits of Putative Female Germline Stem Cells Research in Mammals
title The Controversy, Challenges, and Potential Benefits of Putative Female Germline Stem Cells Research in Mammals
title_full The Controversy, Challenges, and Potential Benefits of Putative Female Germline Stem Cells Research in Mammals
title_fullStr The Controversy, Challenges, and Potential Benefits of Putative Female Germline Stem Cells Research in Mammals
title_full_unstemmed The Controversy, Challenges, and Potential Benefits of Putative Female Germline Stem Cells Research in Mammals
title_short The Controversy, Challenges, and Potential Benefits of Putative Female Germline Stem Cells Research in Mammals
title_sort controversy, challenges, and potential benefits of putative female germline stem cells research in mammals
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693009/
https://www.ncbi.nlm.nih.gov/pubmed/26788065
http://dx.doi.org/10.1155/2016/1728278
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