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Cell Membrane-Coated Nanoparticles As an Emerging Antibacterial Vaccine Platform

Nanoparticles have demonstrated unique advantages in enhancing immunotherapy potency and have drawn increasing interest in developing safe and effective vaccine formulations. Recent technological advancement has led to the discovery and development of cell membrane-coated nanoparticles, which combin...

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Detalles Bibliográficos
Autores principales: Angsantikul, Pavimol, Thamphiwatana, Soracha, Gao, Weiwei, Zhang, Liangfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693220/
https://www.ncbi.nlm.nih.gov/pubmed/26457720
http://dx.doi.org/10.3390/vaccines3040814
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author Angsantikul, Pavimol
Thamphiwatana, Soracha
Gao, Weiwei
Zhang, Liangfang
author_facet Angsantikul, Pavimol
Thamphiwatana, Soracha
Gao, Weiwei
Zhang, Liangfang
author_sort Angsantikul, Pavimol
collection PubMed
description Nanoparticles have demonstrated unique advantages in enhancing immunotherapy potency and have drawn increasing interest in developing safe and effective vaccine formulations. Recent technological advancement has led to the discovery and development of cell membrane-coated nanoparticles, which combine the rich functionalities of cellular membranes and the engineering flexibility of synthetic nanomaterials. This new class of biomimetic nanoparticles has inspired novel vaccine design strategies with strong potential for modulating antibacterial immunity. This article will review recent progress on using cell membrane-coated nanoparticles for antibacterial vaccination. Specifically, two major development strategies will be discussed, namely (i) vaccination against virulence factors through bacterial toxin sequestration; and (ii) vaccination against pathogens through mimicking bacterial antigen presentation.
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spelling pubmed-46932202016-01-07 Cell Membrane-Coated Nanoparticles As an Emerging Antibacterial Vaccine Platform Angsantikul, Pavimol Thamphiwatana, Soracha Gao, Weiwei Zhang, Liangfang Vaccines (Basel) Review Nanoparticles have demonstrated unique advantages in enhancing immunotherapy potency and have drawn increasing interest in developing safe and effective vaccine formulations. Recent technological advancement has led to the discovery and development of cell membrane-coated nanoparticles, which combine the rich functionalities of cellular membranes and the engineering flexibility of synthetic nanomaterials. This new class of biomimetic nanoparticles has inspired novel vaccine design strategies with strong potential for modulating antibacterial immunity. This article will review recent progress on using cell membrane-coated nanoparticles for antibacterial vaccination. Specifically, two major development strategies will be discussed, namely (i) vaccination against virulence factors through bacterial toxin sequestration; and (ii) vaccination against pathogens through mimicking bacterial antigen presentation. MDPI 2015-10-06 /pmc/articles/PMC4693220/ /pubmed/26457720 http://dx.doi.org/10.3390/vaccines3040814 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Angsantikul, Pavimol
Thamphiwatana, Soracha
Gao, Weiwei
Zhang, Liangfang
Cell Membrane-Coated Nanoparticles As an Emerging Antibacterial Vaccine Platform
title Cell Membrane-Coated Nanoparticles As an Emerging Antibacterial Vaccine Platform
title_full Cell Membrane-Coated Nanoparticles As an Emerging Antibacterial Vaccine Platform
title_fullStr Cell Membrane-Coated Nanoparticles As an Emerging Antibacterial Vaccine Platform
title_full_unstemmed Cell Membrane-Coated Nanoparticles As an Emerging Antibacterial Vaccine Platform
title_short Cell Membrane-Coated Nanoparticles As an Emerging Antibacterial Vaccine Platform
title_sort cell membrane-coated nanoparticles as an emerging antibacterial vaccine platform
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693220/
https://www.ncbi.nlm.nih.gov/pubmed/26457720
http://dx.doi.org/10.3390/vaccines3040814
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