RNA-Binding Proteins in the Regulation of miRNA Activity: A Focus on Neuronal Functions

Posttranscriptional modifications of messenger RNAs (mRNAs) are key processes in the fine-tuning of cellular homeostasis. Two major actors in this scenario are RNA binding proteins (RBPs) and microRNAs (miRNAs) that together play important roles in the biogenesis, turnover, translation and localizat...

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Detalles Bibliográficos
Autores principales: Loffreda, Alessia, Rigamonti, Aurora, Barabino, Silvia M. L., Lenzken, Silvia C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693239/
https://www.ncbi.nlm.nih.gov/pubmed/26437437
http://dx.doi.org/10.3390/biom5042363
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author Loffreda, Alessia
Rigamonti, Aurora
Barabino, Silvia M. L.
Lenzken, Silvia C.
author_facet Loffreda, Alessia
Rigamonti, Aurora
Barabino, Silvia M. L.
Lenzken, Silvia C.
author_sort Loffreda, Alessia
collection PubMed
description Posttranscriptional modifications of messenger RNAs (mRNAs) are key processes in the fine-tuning of cellular homeostasis. Two major actors in this scenario are RNA binding proteins (RBPs) and microRNAs (miRNAs) that together play important roles in the biogenesis, turnover, translation and localization of mRNAs. This review will highlight recent advances in the understanding of the role of RBPs in the regulation of the maturation and the function of miRNAs. The interplay between miRNAs and RBPs is discussed specifically in the context of neuronal development and function.
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spelling pubmed-46932392016-01-07 RNA-Binding Proteins in the Regulation of miRNA Activity: A Focus on Neuronal Functions Loffreda, Alessia Rigamonti, Aurora Barabino, Silvia M. L. Lenzken, Silvia C. Biomolecules Review Posttranscriptional modifications of messenger RNAs (mRNAs) are key processes in the fine-tuning of cellular homeostasis. Two major actors in this scenario are RNA binding proteins (RBPs) and microRNAs (miRNAs) that together play important roles in the biogenesis, turnover, translation and localization of mRNAs. This review will highlight recent advances in the understanding of the role of RBPs in the regulation of the maturation and the function of miRNAs. The interplay between miRNAs and RBPs is discussed specifically in the context of neuronal development and function. MDPI 2015-09-30 /pmc/articles/PMC4693239/ /pubmed/26437437 http://dx.doi.org/10.3390/biom5042363 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Loffreda, Alessia
Rigamonti, Aurora
Barabino, Silvia M. L.
Lenzken, Silvia C.
RNA-Binding Proteins in the Regulation of miRNA Activity: A Focus on Neuronal Functions
title RNA-Binding Proteins in the Regulation of miRNA Activity: A Focus on Neuronal Functions
title_full RNA-Binding Proteins in the Regulation of miRNA Activity: A Focus on Neuronal Functions
title_fullStr RNA-Binding Proteins in the Regulation of miRNA Activity: A Focus on Neuronal Functions
title_full_unstemmed RNA-Binding Proteins in the Regulation of miRNA Activity: A Focus on Neuronal Functions
title_short RNA-Binding Proteins in the Regulation of miRNA Activity: A Focus on Neuronal Functions
title_sort rna-binding proteins in the regulation of mirna activity: a focus on neuronal functions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693239/
https://www.ncbi.nlm.nih.gov/pubmed/26437437
http://dx.doi.org/10.3390/biom5042363
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