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Alcohol, Aldehydes, Adducts and Airways

Drinking alcohol and smoking cigarettes results in the formation of reactive aldehydes in the lung, which are capable of forming adducts with several proteins and DNA. Acetaldehyde and malondialdehyde are the major aldehydes generated in high levels in the lung of subjects with alcohol use disorder...

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Detalles Bibliográficos
Autores principales: Sapkota, Muna, Wyatt, Todd A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693266/
https://www.ncbi.nlm.nih.gov/pubmed/26556381
http://dx.doi.org/10.3390/biom5042987
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author Sapkota, Muna
Wyatt, Todd A.
author_facet Sapkota, Muna
Wyatt, Todd A.
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description Drinking alcohol and smoking cigarettes results in the formation of reactive aldehydes in the lung, which are capable of forming adducts with several proteins and DNA. Acetaldehyde and malondialdehyde are the major aldehydes generated in high levels in the lung of subjects with alcohol use disorder who smoke cigarettes. In addition to the above aldehydes, several other aldehydes like 4-hydroxynonenal, formaldehyde and acrolein are also detected in the lung due to exposure to toxic gases, vapors and chemicals. These aldehydes react with nucleophilic targets in cells such as DNA, lipids and proteins to form both stable and unstable adducts. This adduction may disturb cellular functions as well as damage proteins, nucleic acids and lipids. Among several adducts formed in the lung, malondialdehyde DNA (MDA-DNA) adduct and hybrid malondialdehyde-acetaldehyde (MAA) protein adducts have been shown to initiate several pathological conditions in the lung. MDA-DNA adducts are pre-mutagenic in mammalian cells and induce frame shift and base-pair substitution mutations, whereas MAA protein adducts have been shown to induce inflammation and inhibit wound healing. This review provides an insight into different reactive aldehyde adducts and their role in the pathogenesis of lung disease.
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spelling pubmed-46932662016-01-07 Alcohol, Aldehydes, Adducts and Airways Sapkota, Muna Wyatt, Todd A. Biomolecules Review Drinking alcohol and smoking cigarettes results in the formation of reactive aldehydes in the lung, which are capable of forming adducts with several proteins and DNA. Acetaldehyde and malondialdehyde are the major aldehydes generated in high levels in the lung of subjects with alcohol use disorder who smoke cigarettes. In addition to the above aldehydes, several other aldehydes like 4-hydroxynonenal, formaldehyde and acrolein are also detected in the lung due to exposure to toxic gases, vapors and chemicals. These aldehydes react with nucleophilic targets in cells such as DNA, lipids and proteins to form both stable and unstable adducts. This adduction may disturb cellular functions as well as damage proteins, nucleic acids and lipids. Among several adducts formed in the lung, malondialdehyde DNA (MDA-DNA) adduct and hybrid malondialdehyde-acetaldehyde (MAA) protein adducts have been shown to initiate several pathological conditions in the lung. MDA-DNA adducts are pre-mutagenic in mammalian cells and induce frame shift and base-pair substitution mutations, whereas MAA protein adducts have been shown to induce inflammation and inhibit wound healing. This review provides an insight into different reactive aldehyde adducts and their role in the pathogenesis of lung disease. MDPI 2015-11-05 /pmc/articles/PMC4693266/ /pubmed/26556381 http://dx.doi.org/10.3390/biom5042987 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sapkota, Muna
Wyatt, Todd A.
Alcohol, Aldehydes, Adducts and Airways
title Alcohol, Aldehydes, Adducts and Airways
title_full Alcohol, Aldehydes, Adducts and Airways
title_fullStr Alcohol, Aldehydes, Adducts and Airways
title_full_unstemmed Alcohol, Aldehydes, Adducts and Airways
title_short Alcohol, Aldehydes, Adducts and Airways
title_sort alcohol, aldehydes, adducts and airways
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693266/
https://www.ncbi.nlm.nih.gov/pubmed/26556381
http://dx.doi.org/10.3390/biom5042987
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