Expression and Function of CD44 in Epithelial Ovarian Carcinoma

CD44, a cell surface glycoprotein, has been increasingly implicated in the pathogenesis and progression of epithelial ovarian cancer, the deadliest gynecologic malignancy in women. Here, we review recent reports on the expression and function of CD44 in epithelial ovarian carcinoma. Further function...

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Detalles Bibliográficos
Autores principales: Sacks, Joelle D., Barbolina, Maria V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693269/
https://www.ncbi.nlm.nih.gov/pubmed/26569327
http://dx.doi.org/10.3390/biom5043051
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author Sacks, Joelle D.
Barbolina, Maria V.
author_facet Sacks, Joelle D.
Barbolina, Maria V.
author_sort Sacks, Joelle D.
collection PubMed
description CD44, a cell surface glycoprotein, has been increasingly implicated in the pathogenesis and progression of epithelial ovarian cancer, the deadliest gynecologic malignancy in women. Here, we review recent reports on the expression and function of CD44 in epithelial ovarian carcinoma. Further functional data for CD44 in peritoneal adhesion and metastatic progression and its association with stem cells is highlighted. Recent studies utilizing CD44 for therapeutic targeting are also discussed.
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spelling pubmed-46932692016-01-07 Expression and Function of CD44 in Epithelial Ovarian Carcinoma Sacks, Joelle D. Barbolina, Maria V. Biomolecules Review CD44, a cell surface glycoprotein, has been increasingly implicated in the pathogenesis and progression of epithelial ovarian cancer, the deadliest gynecologic malignancy in women. Here, we review recent reports on the expression and function of CD44 in epithelial ovarian carcinoma. Further functional data for CD44 in peritoneal adhesion and metastatic progression and its association with stem cells is highlighted. Recent studies utilizing CD44 for therapeutic targeting are also discussed. MDPI 2015-11-11 /pmc/articles/PMC4693269/ /pubmed/26569327 http://dx.doi.org/10.3390/biom5043051 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sacks, Joelle D.
Barbolina, Maria V.
Expression and Function of CD44 in Epithelial Ovarian Carcinoma
title Expression and Function of CD44 in Epithelial Ovarian Carcinoma
title_full Expression and Function of CD44 in Epithelial Ovarian Carcinoma
title_fullStr Expression and Function of CD44 in Epithelial Ovarian Carcinoma
title_full_unstemmed Expression and Function of CD44 in Epithelial Ovarian Carcinoma
title_short Expression and Function of CD44 in Epithelial Ovarian Carcinoma
title_sort expression and function of cd44 in epithelial ovarian carcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693269/
https://www.ncbi.nlm.nih.gov/pubmed/26569327
http://dx.doi.org/10.3390/biom5043051
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