Making smart investment decisions in clinical research

A recent trial in rheumatoid arthritis found an inexpensive, but infrequently used, combination of therapies is neither inferior nor less safe than an expensive biologic drug. If the trial had been conducted over 10 years ago, arguably 100’s of millions of dollars since spent on biologics could have...

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Autores principales: Bansback, Nick, Keystone, Edward, O’Dell, James, Phibbs, Ciaran S., Hannagan, Keri, Brophy, Mary, Anis, Aslam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693420/
https://www.ncbi.nlm.nih.gov/pubmed/26712327
http://dx.doi.org/10.1186/s13063-015-1123-1
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author Bansback, Nick
Keystone, Edward
O’Dell, James
Phibbs, Ciaran S.
Hannagan, Keri
Brophy, Mary
Anis, Aslam
author_facet Bansback, Nick
Keystone, Edward
O’Dell, James
Phibbs, Ciaran S.
Hannagan, Keri
Brophy, Mary
Anis, Aslam
author_sort Bansback, Nick
collection PubMed
description A recent trial in rheumatoid arthritis found an inexpensive, but infrequently used, combination of therapies is neither inferior nor less safe than an expensive biologic drug. If the trial had been conducted over 10 years ago, arguably 100’s of millions of dollars since spent on biologics could have been released to other, more effective treatments. Given the ever increasing number of trials proposed, this commentary uses the trial as an example to challenge payers and research funders to make smarter investments in clinical research to save potential future costs. Trial registration: NCT00405275, registered 29 November 2006
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spelling pubmed-46934202015-12-30 Making smart investment decisions in clinical research Bansback, Nick Keystone, Edward O’Dell, James Phibbs, Ciaran S. Hannagan, Keri Brophy, Mary Anis, Aslam Trials Commentary A recent trial in rheumatoid arthritis found an inexpensive, but infrequently used, combination of therapies is neither inferior nor less safe than an expensive biologic drug. If the trial had been conducted over 10 years ago, arguably 100’s of millions of dollars since spent on biologics could have been released to other, more effective treatments. Given the ever increasing number of trials proposed, this commentary uses the trial as an example to challenge payers and research funders to make smarter investments in clinical research to save potential future costs. Trial registration: NCT00405275, registered 29 November 2006 BioMed Central 2015-12-29 /pmc/articles/PMC4693420/ /pubmed/26712327 http://dx.doi.org/10.1186/s13063-015-1123-1 Text en © Bansback et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Commentary
Bansback, Nick
Keystone, Edward
O’Dell, James
Phibbs, Ciaran S.
Hannagan, Keri
Brophy, Mary
Anis, Aslam
Making smart investment decisions in clinical research
title Making smart investment decisions in clinical research
title_full Making smart investment decisions in clinical research
title_fullStr Making smart investment decisions in clinical research
title_full_unstemmed Making smart investment decisions in clinical research
title_short Making smart investment decisions in clinical research
title_sort making smart investment decisions in clinical research
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693420/
https://www.ncbi.nlm.nih.gov/pubmed/26712327
http://dx.doi.org/10.1186/s13063-015-1123-1
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