Chronic mTOR inhibition in mice with rapamycin alters T, B, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune‐deficient mice

The mammalian (mechanistic) target of rapamycin (mTOR) regulates critical immune processes that remain incompletely defined. Interest in mTOR inhibitor drugs is heightened by recent demonstrations that the mTOR inhibitor rapamycin extends lifespan and healthspan in mice. Rapamycin or related analogu...

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Detalles Bibliográficos
Autores principales: Hurez, Vincent, Dao, Vinh, Liu, Aijie, Pandeswara, Srilakshmi, Gelfond, Jonathan, Sun, Lishi, Bergman, Molly, Orihuela, Carlos J., Galvan, Veronica, Padrón, Álvaro, Drerup, Justin, Liu, Yang, Hasty, Paul, Sharp, Zelton Dave, Curiel, Tyler J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693453/
https://www.ncbi.nlm.nih.gov/pubmed/26315673
http://dx.doi.org/10.1111/acel.12380

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