Enhanced microglial pro‐inflammatory response to lipopolysaccharide correlates with brain infiltration and blood–brain barrier dysregulation in a mouse model of telomere shortening

Microglia are a proliferative population of resident brain macrophages that under physiological conditions self‐renew independent of hematopoiesis. Microglia are innate immune cells actively surveying the brain and are the earliest responders to injury. During aging, microglia elicit an enhanced inn...

Descripción completa

Detalles Bibliográficos
Autores principales: Raj, Divya D. A., Moser, Jill, van der Pol, Susanne M. A., van Os, Ronald P., Holtman, Inge R., Brouwer, Nieske, Oeseburg, Hisko, Schaafsma, Wandert, Wesseling, Evelyn M., den Dunnen, Wilfred, Biber, Knut P. H., de Vries, Helga E., Eggen, Bart J. L., Boddeke, Hendrikus W. G. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693462/
https://www.ncbi.nlm.nih.gov/pubmed/26238505
http://dx.doi.org/10.1111/acel.12370

Ejemplares similares

Ejemplares similares