The mitochondrial‐derived peptide MOTS‐c: a player in exceptional longevity?

Mitochondrial‐derived peptides (MDP) are encoded by functional short open reading frames in the mitochondrial DNA (mtDNA). These include humanin, and the recently discovered mitochondrial open reading frame of the 12S rRNA‐c (MOTS‐c). Although more research is needed, we suggest that the m.1382A>...

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Autores principales: Fuku, Noriyuki, Pareja‐Galeano, Helios, Zempo, Hirofumi, Alis, Rafael, Arai, Yasumichi, Lucia, Alejandro, Hirose, Nobuyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693465/
https://www.ncbi.nlm.nih.gov/pubmed/26289118
http://dx.doi.org/10.1111/acel.12389
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author Fuku, Noriyuki
Pareja‐Galeano, Helios
Zempo, Hirofumi
Alis, Rafael
Arai, Yasumichi
Lucia, Alejandro
Hirose, Nobuyoshi
author_facet Fuku, Noriyuki
Pareja‐Galeano, Helios
Zempo, Hirofumi
Alis, Rafael
Arai, Yasumichi
Lucia, Alejandro
Hirose, Nobuyoshi
author_sort Fuku, Noriyuki
collection PubMed
description Mitochondrial‐derived peptides (MDP) are encoded by functional short open reading frames in the mitochondrial DNA (mtDNA). These include humanin, and the recently discovered mitochondrial open reading frame of the 12S rRNA‐c (MOTS‐c). Although more research is needed, we suggest that the m.1382A>C polymorphism located in the MOTS‐c encoding mtDNA, which is specific for the Northeast Asian population, may be among the putative biological mechanisms explaining the high longevity of Japanese people.
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spelling pubmed-46934652016-01-04 The mitochondrial‐derived peptide MOTS‐c: a player in exceptional longevity? Fuku, Noriyuki Pareja‐Galeano, Helios Zempo, Hirofumi Alis, Rafael Arai, Yasumichi Lucia, Alejandro Hirose, Nobuyoshi Aging Cell Commentary Mitochondrial‐derived peptides (MDP) are encoded by functional short open reading frames in the mitochondrial DNA (mtDNA). These include humanin, and the recently discovered mitochondrial open reading frame of the 12S rRNA‐c (MOTS‐c). Although more research is needed, we suggest that the m.1382A>C polymorphism located in the MOTS‐c encoding mtDNA, which is specific for the Northeast Asian population, may be among the putative biological mechanisms explaining the high longevity of Japanese people. John Wiley and Sons Inc. 2015-08-20 2015-12 /pmc/articles/PMC4693465/ /pubmed/26289118 http://dx.doi.org/10.1111/acel.12389 Text en © 2015 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Fuku, Noriyuki
Pareja‐Galeano, Helios
Zempo, Hirofumi
Alis, Rafael
Arai, Yasumichi
Lucia, Alejandro
Hirose, Nobuyoshi
The mitochondrial‐derived peptide MOTS‐c: a player in exceptional longevity?
title The mitochondrial‐derived peptide MOTS‐c: a player in exceptional longevity?
title_full The mitochondrial‐derived peptide MOTS‐c: a player in exceptional longevity?
title_fullStr The mitochondrial‐derived peptide MOTS‐c: a player in exceptional longevity?
title_full_unstemmed The mitochondrial‐derived peptide MOTS‐c: a player in exceptional longevity?
title_short The mitochondrial‐derived peptide MOTS‐c: a player in exceptional longevity?
title_sort mitochondrial‐derived peptide mots‐c: a player in exceptional longevity?
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693465/
https://www.ncbi.nlm.nih.gov/pubmed/26289118
http://dx.doi.org/10.1111/acel.12389
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