Loss of IL‐4Rα–mediated PI3K signaling accelerates the progression of IgE/mast cell–mediated reactions

Clinical and experimental evidence indicate that polymorphisms within the interleukin 4 (IL‐4) receptor (IL‐4R) chain are sufficient for altered strength of IL‐4/IL‐13 signaling, leading to an exaggerated allergic inflammatory response and increase susceptibility to allergic phenotypes. In the prese...

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Detalles Bibliográficos
Autores principales: Sledd, Jane, Wu, David, Ahrens, Richard, Lee, Jeebong, Waggoner, Lisa, Tsai, Ying Ting, Wang, Yui‐Hsi, Hogan, Simon P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693723/
https://www.ncbi.nlm.nih.gov/pubmed/26734464
http://dx.doi.org/10.1002/iid3.80

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693723/
https://www.ncbi.nlm.nih.gov/pubmed/26734464
http://dx.doi.org/10.1002/iid3.80

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