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Loss of IL‐4Rα–mediated PI3K signaling accelerates the progression of IgE/mast cell–mediated reactions
Clinical and experimental evidence indicate that polymorphisms within the interleukin 4 (IL‐4) receptor (IL‐4R) chain are sufficient for altered strength of IL‐4/IL‐13 signaling, leading to an exaggerated allergic inflammatory response and increase susceptibility to allergic phenotypes. In the prese...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693723/ https://www.ncbi.nlm.nih.gov/pubmed/26734464 http://dx.doi.org/10.1002/iid3.80 |