Organocatalytic Asymmetric Synthesis of Dihydroisoquinolinones via a One-Pot Aza-Henry–Hemiaminalization–Oxidation Sequence

The asymmetric organocatalytic one-pot synthesis of trans-3,4-disubstituted 3,4-dihydroisoquinolin-1(2H)-ones is described. Starting from 2-(nitromethyl)benzaldehydes and various N-protected aldimines, 5 mol% of a quinine-based squaramide organocatalyst was used to synthesize the title compounds as...

Descripción completa

Detalles Bibliográficos
Autores principales: Hahn, Robert, Jafari, Ehsan, Raabe, Gerhard, Enders, Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693956/
https://www.ncbi.nlm.nih.gov/pubmed/26722132
http://dx.doi.org/10.1055/s-0034-1379398

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693956/
https://www.ncbi.nlm.nih.gov/pubmed/26722132
http://dx.doi.org/10.1055/s-0034-1379398

Ejemplares similares