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Organocatalytic Asymmetric Synthesis of Dihydroisoquinolinones via a One-Pot Aza-Henry–Hemiaminalization–Oxidation Sequence

The asymmetric organocatalytic one-pot synthesis of trans-3,4-disubstituted 3,4-dihydroisoquinolin-1(2H)-ones is described. Starting from 2-(nitromethyl)benzaldehydes and various N-protected aldimines, 5 mol% of a quinine-based squaramide organocatalyst was used to synthesize the title compounds as...

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Detalles Bibliográficos
Autores principales:	Hahn, Robert, Jafari, Ehsan, Raabe, Gerhard, Enders, Dieter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693956/ https://www.ncbi.nlm.nih.gov/pubmed/26722132 http://dx.doi.org/10.1055/s-0034-1379398

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