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Role of Loop-Clamping Side Chains in Catalysis by Triosephosphate Isomerase

[Image: see text] The side chains of Y208 and S211 from loop 7 of triosephosphate isomerase (TIM) form hydrogen bonds to backbone amides and carbonyls from loop 6 to stabilize the caged enzyme–substrate complex. The effect of seven mutations [Y208T, Y208S, Y208A, Y208F, S211G, S211A, Y208T/S211G] on...

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Detalles Bibliográficos
Autores principales:	Zhai, Xiang, Amyes, Tina L., Richard, John P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2015
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694050/ https://www.ncbi.nlm.nih.gov/pubmed/26570983 http://dx.doi.org/10.1021/jacs.5b09328

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