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Association analysis of insulin-like growth factor-1 axis parameters with survival and functional status in nonagenarians of the Leiden Longevity Study

Reduced insulin/insulin-like growth factor 1 (IGF-1) signaling has been associated with longevity in various model organisms. However, the role of insulin/IGF-1 signaling in human survival remains controversial. The aim of this study was to test whether circulating IGF-1 axis parameters associate wi...

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Autores principales: van der Spoel, Evie, Rozing, Maarten P., Houwing-Duistermaat, Jeanine J., Slagboom, P. Eline, Beekman, Marian, de Craen, Anton J.M., Westendorp, Rudi G.J., van Heemst, Diana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694065/
https://www.ncbi.nlm.nih.gov/pubmed/26568155
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author van der Spoel, Evie
Rozing, Maarten P.
Houwing-Duistermaat, Jeanine J.
Slagboom, P. Eline
Beekman, Marian
de Craen, Anton J.M.
Westendorp, Rudi G.J.
van Heemst, Diana
author_facet van der Spoel, Evie
Rozing, Maarten P.
Houwing-Duistermaat, Jeanine J.
Slagboom, P. Eline
Beekman, Marian
de Craen, Anton J.M.
Westendorp, Rudi G.J.
van Heemst, Diana
author_sort van der Spoel, Evie
collection PubMed
description Reduced insulin/insulin-like growth factor 1 (IGF-1) signaling has been associated with longevity in various model organisms. However, the role of insulin/IGF-1 signaling in human survival remains controversial. The aim of this study was to test whether circulating IGF-1 axis parameters associate with old age survival and functional status in nonagenarians from the Leiden Longevity Study. This study examined 858 Dutch nonagenarian (males≥89 years; females≥91 years) siblings from 409 families, without selection on health or demographic characteristics. Nonagenarians were divided over sex-specific strata according to their levels of IGF-1, IGF binding protein 3 and IGF-1/IGFBP3 molar ratio. We found that lower IGF-1/IGFBP3 ratios were associated with improved survival: nonagenarians in the quartile of the lowest ratio had a lower estimated hazard ratio (95% confidence interval) of 0.73 (0.59 – 0.91) compared to the quartile with the highest ratio (p(trend)=0.002). Functional status was assessed by (Instrumental) Activities of Daily Living ((I)ADL) scales. Compared to those in the quartile with the highest IGF-1/IGFBP3 ratio, nonagenarians in the lowest quartile had higher scores for ADL (p(trend)=0.001) and IADL (p(trend)=0.003). These findings suggest that IGF-1 axis parameters are associated with increased old age survival and better functional status in nonagenarians from the Leiden Longevity Study.
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spelling pubmed-46940652016-01-07 Association analysis of insulin-like growth factor-1 axis parameters with survival and functional status in nonagenarians of the Leiden Longevity Study van der Spoel, Evie Rozing, Maarten P. Houwing-Duistermaat, Jeanine J. Slagboom, P. Eline Beekman, Marian de Craen, Anton J.M. Westendorp, Rudi G.J. van Heemst, Diana Aging (Albany NY) Research Paper Reduced insulin/insulin-like growth factor 1 (IGF-1) signaling has been associated with longevity in various model organisms. However, the role of insulin/IGF-1 signaling in human survival remains controversial. The aim of this study was to test whether circulating IGF-1 axis parameters associate with old age survival and functional status in nonagenarians from the Leiden Longevity Study. This study examined 858 Dutch nonagenarian (males≥89 years; females≥91 years) siblings from 409 families, without selection on health or demographic characteristics. Nonagenarians were divided over sex-specific strata according to their levels of IGF-1, IGF binding protein 3 and IGF-1/IGFBP3 molar ratio. We found that lower IGF-1/IGFBP3 ratios were associated with improved survival: nonagenarians in the quartile of the lowest ratio had a lower estimated hazard ratio (95% confidence interval) of 0.73 (0.59 – 0.91) compared to the quartile with the highest ratio (p(trend)=0.002). Functional status was assessed by (Instrumental) Activities of Daily Living ((I)ADL) scales. Compared to those in the quartile with the highest IGF-1/IGFBP3 ratio, nonagenarians in the lowest quartile had higher scores for ADL (p(trend)=0.001) and IADL (p(trend)=0.003). These findings suggest that IGF-1 axis parameters are associated with increased old age survival and better functional status in nonagenarians from the Leiden Longevity Study. Impact Journals LLC 2015-11-12 /pmc/articles/PMC4694065/ /pubmed/26568155 Text en Copyright: © 2015 van der Spoel et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
van der Spoel, Evie
Rozing, Maarten P.
Houwing-Duistermaat, Jeanine J.
Slagboom, P. Eline
Beekman, Marian
de Craen, Anton J.M.
Westendorp, Rudi G.J.
van Heemst, Diana
Association analysis of insulin-like growth factor-1 axis parameters with survival and functional status in nonagenarians of the Leiden Longevity Study
title Association analysis of insulin-like growth factor-1 axis parameters with survival and functional status in nonagenarians of the Leiden Longevity Study
title_full Association analysis of insulin-like growth factor-1 axis parameters with survival and functional status in nonagenarians of the Leiden Longevity Study
title_fullStr Association analysis of insulin-like growth factor-1 axis parameters with survival and functional status in nonagenarians of the Leiden Longevity Study
title_full_unstemmed Association analysis of insulin-like growth factor-1 axis parameters with survival and functional status in nonagenarians of the Leiden Longevity Study
title_short Association analysis of insulin-like growth factor-1 axis parameters with survival and functional status in nonagenarians of the Leiden Longevity Study
title_sort association analysis of insulin-like growth factor-1 axis parameters with survival and functional status in nonagenarians of the leiden longevity study
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694065/
https://www.ncbi.nlm.nih.gov/pubmed/26568155
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