Inhibition of Hedgehog-Signaling Driven Genes in Prostate Cancer Cells by Sutherlandia frutescens Extract

Sutherlandia frutescens (L) R. Br. (Sutherlandia) is a South African botanical that is traditionally used to treat a variety of health conditions, infections and diseases, including cancer. We hypothesized Sutherlandia might act through Gli/ Hedgehog (Hh)-signaling in prostate cancer cells and used...

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Detalles Bibliográficos
Autores principales: Lu, Yuan, Starkey, Nicholas, Lei, Wei, Li, Jilong, Cheng, Jianlin, Folk, William R., Lubahn, Dennis B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694108/
https://www.ncbi.nlm.nih.gov/pubmed/26710108
http://dx.doi.org/10.1371/journal.pone.0145507
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author Lu, Yuan
Starkey, Nicholas
Lei, Wei
Li, Jilong
Cheng, Jianlin
Folk, William R.
Lubahn, Dennis B.
author_facet Lu, Yuan
Starkey, Nicholas
Lei, Wei
Li, Jilong
Cheng, Jianlin
Folk, William R.
Lubahn, Dennis B.
author_sort Lu, Yuan
collection PubMed
description Sutherlandia frutescens (L) R. Br. (Sutherlandia) is a South African botanical that is traditionally used to treat a variety of health conditions, infections and diseases, including cancer. We hypothesized Sutherlandia might act through Gli/ Hedgehog (Hh)-signaling in prostate cancer cells and used RNA-Seq transcription profiling to profile gene expression in TRAMPC2 murine prostate cancer cells with or without Sutherlandia extracts. We found 50% of Hh-responsive genes can be repressed by Sutherlandia ethanol extract, including the canonical Hh-responsive genes Gli1 and Ptch1 as well as newly distinguished Hh-responsive genes Hsd11b1 and Penk.
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spelling pubmed-46941082016-01-12 Inhibition of Hedgehog-Signaling Driven Genes in Prostate Cancer Cells by Sutherlandia frutescens Extract Lu, Yuan Starkey, Nicholas Lei, Wei Li, Jilong Cheng, Jianlin Folk, William R. Lubahn, Dennis B. PLoS One Research Article Sutherlandia frutescens (L) R. Br. (Sutherlandia) is a South African botanical that is traditionally used to treat a variety of health conditions, infections and diseases, including cancer. We hypothesized Sutherlandia might act through Gli/ Hedgehog (Hh)-signaling in prostate cancer cells and used RNA-Seq transcription profiling to profile gene expression in TRAMPC2 murine prostate cancer cells with or without Sutherlandia extracts. We found 50% of Hh-responsive genes can be repressed by Sutherlandia ethanol extract, including the canonical Hh-responsive genes Gli1 and Ptch1 as well as newly distinguished Hh-responsive genes Hsd11b1 and Penk. Public Library of Science 2015-12-28 /pmc/articles/PMC4694108/ /pubmed/26710108 http://dx.doi.org/10.1371/journal.pone.0145507 Text en © 2015 Lu et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Lu, Yuan
Starkey, Nicholas
Lei, Wei
Li, Jilong
Cheng, Jianlin
Folk, William R.
Lubahn, Dennis B.
Inhibition of Hedgehog-Signaling Driven Genes in Prostate Cancer Cells by Sutherlandia frutescens Extract
title Inhibition of Hedgehog-Signaling Driven Genes in Prostate Cancer Cells by Sutherlandia frutescens Extract
title_full Inhibition of Hedgehog-Signaling Driven Genes in Prostate Cancer Cells by Sutherlandia frutescens Extract
title_fullStr Inhibition of Hedgehog-Signaling Driven Genes in Prostate Cancer Cells by Sutherlandia frutescens Extract
title_full_unstemmed Inhibition of Hedgehog-Signaling Driven Genes in Prostate Cancer Cells by Sutherlandia frutescens Extract
title_short Inhibition of Hedgehog-Signaling Driven Genes in Prostate Cancer Cells by Sutherlandia frutescens Extract
title_sort inhibition of hedgehog-signaling driven genes in prostate cancer cells by sutherlandia frutescens extract
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694108/
https://www.ncbi.nlm.nih.gov/pubmed/26710108
http://dx.doi.org/10.1371/journal.pone.0145507
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