Alkaline Phosphatase-Positive Immortal Mouse Embryo Fibroblasts Are Cells in a Transitional Reprogramming State Induced to Face Environmental Stresses

In this study, we report that immortal mouse embryonic fibroblasts (I-MEFs) have a baseline level of cells positive for alkaline phosphatase (AP(+)) staining. Environmental stresses, including long-lasting growth in the absence of expansion and treatment with drugs, enhance the frequency of AP(+) I-...

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Detalles Bibliográficos
Autores principales: Evangelista, Monica, Baroudi, Mariama El, Rizzo, Milena, Tuccoli, Andrea, Poliseno, Laura, Pellegrini, Marco, Rainaldi, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694620/
https://www.ncbi.nlm.nih.gov/pubmed/26740745
http://dx.doi.org/10.4137/GEG.S27696

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