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Control of bleeding in surgical procedures: critical appraisal of HEMOPATCH (Sealing Hemostat)

The need for advanced hemostatic agents increases with the complexity of surgical procedures and use of anticoagulation and antiplatelet treatments. HEMOPATCH (Sealing Hemostat) is a novel, advanced hemostatic pad that is composed of a synthetic, protein-reactive monomer and a collagen backing. The...

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Detalles Bibliográficos
Autores principales: Lewis, Kevin Michael, Kuntze, Carl Erik, Gulle, Heinz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694675/
https://www.ncbi.nlm.nih.gov/pubmed/26730213
http://dx.doi.org/10.2147/MDER.S90591
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author Lewis, Kevin Michael
Kuntze, Carl Erik
Gulle, Heinz
author_facet Lewis, Kevin Michael
Kuntze, Carl Erik
Gulle, Heinz
author_sort Lewis, Kevin Michael
collection PubMed
description The need for advanced hemostatic agents increases with the complexity of surgical procedures and use of anticoagulation and antiplatelet treatments. HEMOPATCH (Sealing Hemostat) is a novel, advanced hemostatic pad that is composed of a synthetic, protein-reactive monomer and a collagen backing. The active side is covered with a protein-reactive monomer: N-hydroxysuccinimide functionalized polyethylene glycol (NHS-PEG). NHS-PEG rapidly affixes the collagen pad to tissue to promote and maintain hemostasis. The combined action of the NHS-PEG and collagen is demonstrated to have benefit relative to other hemostatic agents in surgery and preclinical surgical models. This paper reviews the published investigations and case reports of the hemostatic efficacy of HEMOPATCH, wherein HEMOPATCH is demonstrated to be an effective, easy-to-use hemostatic agent in open and minimally invasive surgery of patients with thrombin- or platelet-induced coagulopathies.
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spelling pubmed-46946752016-01-04 Control of bleeding in surgical procedures: critical appraisal of HEMOPATCH (Sealing Hemostat) Lewis, Kevin Michael Kuntze, Carl Erik Gulle, Heinz Med Devices (Auckl) Review The need for advanced hemostatic agents increases with the complexity of surgical procedures and use of anticoagulation and antiplatelet treatments. HEMOPATCH (Sealing Hemostat) is a novel, advanced hemostatic pad that is composed of a synthetic, protein-reactive monomer and a collagen backing. The active side is covered with a protein-reactive monomer: N-hydroxysuccinimide functionalized polyethylene glycol (NHS-PEG). NHS-PEG rapidly affixes the collagen pad to tissue to promote and maintain hemostasis. The combined action of the NHS-PEG and collagen is demonstrated to have benefit relative to other hemostatic agents in surgery and preclinical surgical models. This paper reviews the published investigations and case reports of the hemostatic efficacy of HEMOPATCH, wherein HEMOPATCH is demonstrated to be an effective, easy-to-use hemostatic agent in open and minimally invasive surgery of patients with thrombin- or platelet-induced coagulopathies. Dove Medical Press 2015-12-22 /pmc/articles/PMC4694675/ /pubmed/26730213 http://dx.doi.org/10.2147/MDER.S90591 Text en © 2016 Lewis et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Lewis, Kevin Michael
Kuntze, Carl Erik
Gulle, Heinz
Control of bleeding in surgical procedures: critical appraisal of HEMOPATCH (Sealing Hemostat)
title Control of bleeding in surgical procedures: critical appraisal of HEMOPATCH (Sealing Hemostat)
title_full Control of bleeding in surgical procedures: critical appraisal of HEMOPATCH (Sealing Hemostat)
title_fullStr Control of bleeding in surgical procedures: critical appraisal of HEMOPATCH (Sealing Hemostat)
title_full_unstemmed Control of bleeding in surgical procedures: critical appraisal of HEMOPATCH (Sealing Hemostat)
title_short Control of bleeding in surgical procedures: critical appraisal of HEMOPATCH (Sealing Hemostat)
title_sort control of bleeding in surgical procedures: critical appraisal of hemopatch (sealing hemostat)
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694675/
https://www.ncbi.nlm.nih.gov/pubmed/26730213
http://dx.doi.org/10.2147/MDER.S90591
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