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Genetic variants in insulin-like growth factor binding protein-3 are associated with prostate cancer susceptibility in Eastern Chinese Han men
BACKGROUND: Growing evidence has indicated that insulin-like growth factor binding protein-3 (IGFBP-3) polymorphisms are associated with altered risk of prostate cancer (PCa). However, few studies have been conducted in Chinese population to validate this association. MATERIALS AND METHODS: Herein,...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694676/ https://www.ncbi.nlm.nih.gov/pubmed/26730204 http://dx.doi.org/10.2147/OTT.S96294 |
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author | Zhang, Guiming Zhu, Yao Liu, Fang Gu, Chengyuan Chen, Haitao Xu, Jianfeng Ye, Dingwei |
author_facet | Zhang, Guiming Zhu, Yao Liu, Fang Gu, Chengyuan Chen, Haitao Xu, Jianfeng Ye, Dingwei |
author_sort | Zhang, Guiming |
collection | PubMed |
description | BACKGROUND: Growing evidence has indicated that insulin-like growth factor binding protein-3 (IGFBP-3) polymorphisms are associated with altered risk of prostate cancer (PCa). However, few studies have been conducted in Chinese population to validate this association. MATERIALS AND METHODS: Herein, we examined the association between genetic variants in the IGFBP-3 gene and PCa risk in the Chinese Han population based on a genome-wide association study (1,417 cases and 1,008 controls), and replicated three genetic variants loci in an independent case-control study (1,755 cases and 1,523 controls) using Sequenom platform. Logistic regression analyses were performed to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs). RESULTS: We found that in the discovery stage, rs9691259 (OR =0.691, 95% CI: 0.587–0.814, P<0.001) and rs6950179 (OR =1.420, 95% CI: 1.201–1.677, P<0.001) were significantly associated with PCa risk, whereas rs2854744 showed a marginal association with PCa risk. In the replication stage, the association between rs9691259 and rs6950179 and PCa risk was not replicated, whereas rs2854744 conferred a significant association with PCa risk (OR =1.399, 95% CI: 1.010–1.937, P=0.043). After combining the two stages, we found that rs9691259, rs6950179, and rs2854744 were all significantly associated with PCa risk. CONCLUSION: This study suggests that IGFBP-3 genetic variants are significantly associated with PCa risk in the Chinese population. |
format | Online Article Text |
id | pubmed-4694676 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-46946762016-01-04 Genetic variants in insulin-like growth factor binding protein-3 are associated with prostate cancer susceptibility in Eastern Chinese Han men Zhang, Guiming Zhu, Yao Liu, Fang Gu, Chengyuan Chen, Haitao Xu, Jianfeng Ye, Dingwei Onco Targets Ther Original Research BACKGROUND: Growing evidence has indicated that insulin-like growth factor binding protein-3 (IGFBP-3) polymorphisms are associated with altered risk of prostate cancer (PCa). However, few studies have been conducted in Chinese population to validate this association. MATERIALS AND METHODS: Herein, we examined the association between genetic variants in the IGFBP-3 gene and PCa risk in the Chinese Han population based on a genome-wide association study (1,417 cases and 1,008 controls), and replicated three genetic variants loci in an independent case-control study (1,755 cases and 1,523 controls) using Sequenom platform. Logistic regression analyses were performed to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs). RESULTS: We found that in the discovery stage, rs9691259 (OR =0.691, 95% CI: 0.587–0.814, P<0.001) and rs6950179 (OR =1.420, 95% CI: 1.201–1.677, P<0.001) were significantly associated with PCa risk, whereas rs2854744 showed a marginal association with PCa risk. In the replication stage, the association between rs9691259 and rs6950179 and PCa risk was not replicated, whereas rs2854744 conferred a significant association with PCa risk (OR =1.399, 95% CI: 1.010–1.937, P=0.043). After combining the two stages, we found that rs9691259, rs6950179, and rs2854744 were all significantly associated with PCa risk. CONCLUSION: This study suggests that IGFBP-3 genetic variants are significantly associated with PCa risk in the Chinese population. Dove Medical Press 2015-12-22 /pmc/articles/PMC4694676/ /pubmed/26730204 http://dx.doi.org/10.2147/OTT.S96294 Text en © 2016 Zhang et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Zhang, Guiming Zhu, Yao Liu, Fang Gu, Chengyuan Chen, Haitao Xu, Jianfeng Ye, Dingwei Genetic variants in insulin-like growth factor binding protein-3 are associated with prostate cancer susceptibility in Eastern Chinese Han men |
title | Genetic variants in insulin-like growth factor binding protein-3 are associated with prostate cancer susceptibility in Eastern Chinese Han men |
title_full | Genetic variants in insulin-like growth factor binding protein-3 are associated with prostate cancer susceptibility in Eastern Chinese Han men |
title_fullStr | Genetic variants in insulin-like growth factor binding protein-3 are associated with prostate cancer susceptibility in Eastern Chinese Han men |
title_full_unstemmed | Genetic variants in insulin-like growth factor binding protein-3 are associated with prostate cancer susceptibility in Eastern Chinese Han men |
title_short | Genetic variants in insulin-like growth factor binding protein-3 are associated with prostate cancer susceptibility in Eastern Chinese Han men |
title_sort | genetic variants in insulin-like growth factor binding protein-3 are associated with prostate cancer susceptibility in eastern chinese han men |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694676/ https://www.ncbi.nlm.nih.gov/pubmed/26730204 http://dx.doi.org/10.2147/OTT.S96294 |
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