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Genetic variants in insulin-like growth factor binding protein-3 are associated with prostate cancer susceptibility in Eastern Chinese Han men

BACKGROUND: Growing evidence has indicated that insulin-like growth factor binding protein-3 (IGFBP-3) polymorphisms are associated with altered risk of prostate cancer (PCa). However, few studies have been conducted in Chinese population to validate this association. MATERIALS AND METHODS: Herein,...

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Autores principales: Zhang, Guiming, Zhu, Yao, Liu, Fang, Gu, Chengyuan, Chen, Haitao, Xu, Jianfeng, Ye, Dingwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694676/
https://www.ncbi.nlm.nih.gov/pubmed/26730204
http://dx.doi.org/10.2147/OTT.S96294
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author Zhang, Guiming
Zhu, Yao
Liu, Fang
Gu, Chengyuan
Chen, Haitao
Xu, Jianfeng
Ye, Dingwei
author_facet Zhang, Guiming
Zhu, Yao
Liu, Fang
Gu, Chengyuan
Chen, Haitao
Xu, Jianfeng
Ye, Dingwei
author_sort Zhang, Guiming
collection PubMed
description BACKGROUND: Growing evidence has indicated that insulin-like growth factor binding protein-3 (IGFBP-3) polymorphisms are associated with altered risk of prostate cancer (PCa). However, few studies have been conducted in Chinese population to validate this association. MATERIALS AND METHODS: Herein, we examined the association between genetic variants in the IGFBP-3 gene and PCa risk in the Chinese Han population based on a genome-wide association study (1,417 cases and 1,008 controls), and replicated three genetic variants loci in an independent case-control study (1,755 cases and 1,523 controls) using Sequenom platform. Logistic regression analyses were performed to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs). RESULTS: We found that in the discovery stage, rs9691259 (OR =0.691, 95% CI: 0.587–0.814, P<0.001) and rs6950179 (OR =1.420, 95% CI: 1.201–1.677, P<0.001) were significantly associated with PCa risk, whereas rs2854744 showed a marginal association with PCa risk. In the replication stage, the association between rs9691259 and rs6950179 and PCa risk was not replicated, whereas rs2854744 conferred a significant association with PCa risk (OR =1.399, 95% CI: 1.010–1.937, P=0.043). After combining the two stages, we found that rs9691259, rs6950179, and rs2854744 were all significantly associated with PCa risk. CONCLUSION: This study suggests that IGFBP-3 genetic variants are significantly associated with PCa risk in the Chinese population.
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spelling pubmed-46946762016-01-04 Genetic variants in insulin-like growth factor binding protein-3 are associated with prostate cancer susceptibility in Eastern Chinese Han men Zhang, Guiming Zhu, Yao Liu, Fang Gu, Chengyuan Chen, Haitao Xu, Jianfeng Ye, Dingwei Onco Targets Ther Original Research BACKGROUND: Growing evidence has indicated that insulin-like growth factor binding protein-3 (IGFBP-3) polymorphisms are associated with altered risk of prostate cancer (PCa). However, few studies have been conducted in Chinese population to validate this association. MATERIALS AND METHODS: Herein, we examined the association between genetic variants in the IGFBP-3 gene and PCa risk in the Chinese Han population based on a genome-wide association study (1,417 cases and 1,008 controls), and replicated three genetic variants loci in an independent case-control study (1,755 cases and 1,523 controls) using Sequenom platform. Logistic regression analyses were performed to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs). RESULTS: We found that in the discovery stage, rs9691259 (OR =0.691, 95% CI: 0.587–0.814, P<0.001) and rs6950179 (OR =1.420, 95% CI: 1.201–1.677, P<0.001) were significantly associated with PCa risk, whereas rs2854744 showed a marginal association with PCa risk. In the replication stage, the association between rs9691259 and rs6950179 and PCa risk was not replicated, whereas rs2854744 conferred a significant association with PCa risk (OR =1.399, 95% CI: 1.010–1.937, P=0.043). After combining the two stages, we found that rs9691259, rs6950179, and rs2854744 were all significantly associated with PCa risk. CONCLUSION: This study suggests that IGFBP-3 genetic variants are significantly associated with PCa risk in the Chinese population. Dove Medical Press 2015-12-22 /pmc/articles/PMC4694676/ /pubmed/26730204 http://dx.doi.org/10.2147/OTT.S96294 Text en © 2016 Zhang et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Zhang, Guiming
Zhu, Yao
Liu, Fang
Gu, Chengyuan
Chen, Haitao
Xu, Jianfeng
Ye, Dingwei
Genetic variants in insulin-like growth factor binding protein-3 are associated with prostate cancer susceptibility in Eastern Chinese Han men
title Genetic variants in insulin-like growth factor binding protein-3 are associated with prostate cancer susceptibility in Eastern Chinese Han men
title_full Genetic variants in insulin-like growth factor binding protein-3 are associated with prostate cancer susceptibility in Eastern Chinese Han men
title_fullStr Genetic variants in insulin-like growth factor binding protein-3 are associated with prostate cancer susceptibility in Eastern Chinese Han men
title_full_unstemmed Genetic variants in insulin-like growth factor binding protein-3 are associated with prostate cancer susceptibility in Eastern Chinese Han men
title_short Genetic variants in insulin-like growth factor binding protein-3 are associated with prostate cancer susceptibility in Eastern Chinese Han men
title_sort genetic variants in insulin-like growth factor binding protein-3 are associated with prostate cancer susceptibility in eastern chinese han men
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694676/
https://www.ncbi.nlm.nih.gov/pubmed/26730204
http://dx.doi.org/10.2147/OTT.S96294
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