Novel Inducers of Fetal Globin Identified through High Throughput Screening (HTS) Are Active In Vivo in Anemic Baboons and Transgenic Mice

High-level fetal (γ) globin expression ameliorates clinical severity of the beta (β) hemoglobinopathies, and safe, orally-bioavailable γ-globin inducing agents would benefit many patients. We adapted a LCR-γ-globin promoter-GFP reporter assay to a high-throughput robotic system to evaluate five dive...

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Detalles Bibliográficos
Autores principales: Boosalis, Michael S., Sangerman, Jose I., White, Gary L., Wolf, Roman F., Shen, Ling, Dai, Yan, White, Emily, Makala, Levi H., Li, Biaoru, Pace, Betty S., Nouraie, Mehdi, Faller, Douglas V., Perrine, Susan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694699/
https://www.ncbi.nlm.nih.gov/pubmed/26713848
http://dx.doi.org/10.1371/journal.pone.0144660

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