Evasion of Immunity to Plasmodium falciparum: Rosettes of Blood Group A Impair Recognition of PfEMP1

The ABO blood group antigens are expressed on erythrocytes but also on endothelial cells, platelets and serum proteins. Notably, the ABO blood group of a malaria patient determines the development of the disease given that blood group O reduces the probability to succumb in severe malaria, compared...

Descripción completa

Detalles Bibliográficos
Autores principales: Moll, Kirsten, Palmkvist, Mia, Ch'ng, Junhong, Kiwuwa, Mpungu Steven, Wahlgren, Mats
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694710/
https://www.ncbi.nlm.nih.gov/pubmed/26714011
http://dx.doi.org/10.1371/journal.pone.0145120
_version_ 1782407505433853952
author Moll, Kirsten
Palmkvist, Mia
Ch'ng, Junhong
Kiwuwa, Mpungu Steven
Wahlgren, Mats
author_facet Moll, Kirsten
Palmkvist, Mia
Ch'ng, Junhong
Kiwuwa, Mpungu Steven
Wahlgren, Mats
author_sort Moll, Kirsten
collection PubMed
description The ABO blood group antigens are expressed on erythrocytes but also on endothelial cells, platelets and serum proteins. Notably, the ABO blood group of a malaria patient determines the development of the disease given that blood group O reduces the probability to succumb in severe malaria, compared to individuals of groups A, B or AB. P. falciparum rosetting and sequestration are mediated by PfEMP1, RIFIN and STEVOR, expressed at the surface of the parasitized red blood cell (pRBC). Antibodies to these antigens consequently modify the course of a malaria infection by preventing sequestration and promoting phagocytosis of pRBC. Here we have studied rosetting P. falciparum and present evidence of an immune evasion mechanism not previously recognized. We find the accessibility of antibodies to PfEMP1 at the surface of the pRBC to be reduced when P. falciparum forms rosettes in blood group A RBC, as compared to group O RBC. The pRBC surrounds itself with tightly bound normal RBC that makes PfEMP1 inaccessible to antibodies and clearance by the immune system. Accordingly, pRBC of in vitro cloned P. falciparum devoid of ABO blood group dependent rosetting were equally well detected by anti-PfEMP1 antibodies, independent of the blood group utilized for their propagation. The pathogenic mechanisms underlying the severe forms of malaria may in patients of blood group A depend on the ability of the parasite to mask PfEMP1 from antibody recognition, in so doing evading immune clearance.
format Online
Article
Text
id pubmed-4694710
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-46947102016-01-13 Evasion of Immunity to Plasmodium falciparum: Rosettes of Blood Group A Impair Recognition of PfEMP1 Moll, Kirsten Palmkvist, Mia Ch'ng, Junhong Kiwuwa, Mpungu Steven Wahlgren, Mats PLoS One Research Article The ABO blood group antigens are expressed on erythrocytes but also on endothelial cells, platelets and serum proteins. Notably, the ABO blood group of a malaria patient determines the development of the disease given that blood group O reduces the probability to succumb in severe malaria, compared to individuals of groups A, B or AB. P. falciparum rosetting and sequestration are mediated by PfEMP1, RIFIN and STEVOR, expressed at the surface of the parasitized red blood cell (pRBC). Antibodies to these antigens consequently modify the course of a malaria infection by preventing sequestration and promoting phagocytosis of pRBC. Here we have studied rosetting P. falciparum and present evidence of an immune evasion mechanism not previously recognized. We find the accessibility of antibodies to PfEMP1 at the surface of the pRBC to be reduced when P. falciparum forms rosettes in blood group A RBC, as compared to group O RBC. The pRBC surrounds itself with tightly bound normal RBC that makes PfEMP1 inaccessible to antibodies and clearance by the immune system. Accordingly, pRBC of in vitro cloned P. falciparum devoid of ABO blood group dependent rosetting were equally well detected by anti-PfEMP1 antibodies, independent of the blood group utilized for their propagation. The pathogenic mechanisms underlying the severe forms of malaria may in patients of blood group A depend on the ability of the parasite to mask PfEMP1 from antibody recognition, in so doing evading immune clearance. Public Library of Science 2015-12-29 /pmc/articles/PMC4694710/ /pubmed/26714011 http://dx.doi.org/10.1371/journal.pone.0145120 Text en © 2015 Moll et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Moll, Kirsten
Palmkvist, Mia
Ch'ng, Junhong
Kiwuwa, Mpungu Steven
Wahlgren, Mats
Evasion of Immunity to Plasmodium falciparum: Rosettes of Blood Group A Impair Recognition of PfEMP1
title Evasion of Immunity to Plasmodium falciparum: Rosettes of Blood Group A Impair Recognition of PfEMP1
title_full Evasion of Immunity to Plasmodium falciparum: Rosettes of Blood Group A Impair Recognition of PfEMP1
title_fullStr Evasion of Immunity to Plasmodium falciparum: Rosettes of Blood Group A Impair Recognition of PfEMP1
title_full_unstemmed Evasion of Immunity to Plasmodium falciparum: Rosettes of Blood Group A Impair Recognition of PfEMP1
title_short Evasion of Immunity to Plasmodium falciparum: Rosettes of Blood Group A Impair Recognition of PfEMP1
title_sort evasion of immunity to plasmodium falciparum: rosettes of blood group a impair recognition of pfemp1
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694710/
https://www.ncbi.nlm.nih.gov/pubmed/26714011
http://dx.doi.org/10.1371/journal.pone.0145120
work_keys_str_mv AT mollkirsten evasionofimmunitytoplasmodiumfalciparumrosettesofbloodgroupaimpairrecognitionofpfemp1
AT palmkvistmia evasionofimmunitytoplasmodiumfalciparumrosettesofbloodgroupaimpairrecognitionofpfemp1
AT chngjunhong evasionofimmunitytoplasmodiumfalciparumrosettesofbloodgroupaimpairrecognitionofpfemp1
AT kiwuwampungusteven evasionofimmunitytoplasmodiumfalciparumrosettesofbloodgroupaimpairrecognitionofpfemp1
AT wahlgrenmats evasionofimmunitytoplasmodiumfalciparumrosettesofbloodgroupaimpairrecognitionofpfemp1