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Esophageal Mast Cell Infiltration in a 32-Year-Old Woman with Noncardiac Chest Pain
Noncardiac chest pain (NCCP) is one of the most common esophageal symptoms and lacks a clearly defined mechanism. The most common cause of NCCP is gastroesophageal reflux disease (GERD). One of the accepted mechanisms of NCCP in a patient without GERD has been altered visceral sensitivity. Mast cell...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Editorial Office of Gut and Liver
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694748/ https://www.ncbi.nlm.nih.gov/pubmed/26087786 http://dx.doi.org/10.5009/gnl14294 |
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author | Lee, Keol Kwon, Hee Jin Kim, In Young Yoo, Kwai Han Lee, Seulkee Min, Yang Won Rhee, Poong-Lyul |
author_facet | Lee, Keol Kwon, Hee Jin Kim, In Young Yoo, Kwai Han Lee, Seulkee Min, Yang Won Rhee, Poong-Lyul |
author_sort | Lee, Keol |
collection | PubMed |
description | Noncardiac chest pain (NCCP) is one of the most common esophageal symptoms and lacks a clearly defined mechanism. The most common cause of NCCP is gastroesophageal reflux disease (GERD). One of the accepted mechanisms of NCCP in a patient without GERD has been altered visceral sensitivity. Mast cells may play a role in visceral hypersensitivity in irritable bowel syndrome. In this case, a patient with NCCP and dysphagia who was unresponsive to proton pump inhibitor treatment had an increased esophageal mast cell infiltration and responded to 14 days of antihistamine and antileukotriene treatment. We suggest that there may be a relationship between esophageal symptoms such as NCCP and esophageal mast cell infiltration. |
format | Online Article Text |
id | pubmed-4694748 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Editorial Office of Gut and Liver |
record_format | MEDLINE/PubMed |
spelling | pubmed-46947482016-01-20 Esophageal Mast Cell Infiltration in a 32-Year-Old Woman with Noncardiac Chest Pain Lee, Keol Kwon, Hee Jin Kim, In Young Yoo, Kwai Han Lee, Seulkee Min, Yang Won Rhee, Poong-Lyul Gut Liver Brief Communication Noncardiac chest pain (NCCP) is one of the most common esophageal symptoms and lacks a clearly defined mechanism. The most common cause of NCCP is gastroesophageal reflux disease (GERD). One of the accepted mechanisms of NCCP in a patient without GERD has been altered visceral sensitivity. Mast cells may play a role in visceral hypersensitivity in irritable bowel syndrome. In this case, a patient with NCCP and dysphagia who was unresponsive to proton pump inhibitor treatment had an increased esophageal mast cell infiltration and responded to 14 days of antihistamine and antileukotriene treatment. We suggest that there may be a relationship between esophageal symptoms such as NCCP and esophageal mast cell infiltration. Editorial Office of Gut and Liver 2016-01 2016-01-15 /pmc/articles/PMC4694748/ /pubmed/26087786 http://dx.doi.org/10.5009/gnl14294 Text en Copyright © 2016 by The Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, Korean College of Helicobacter and Upper Gastrointestinal Research, Korean Association the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, Korean Pancreatobiliary Association, and Korean Society of Gastrointestinal Cancer. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Brief Communication Lee, Keol Kwon, Hee Jin Kim, In Young Yoo, Kwai Han Lee, Seulkee Min, Yang Won Rhee, Poong-Lyul Esophageal Mast Cell Infiltration in a 32-Year-Old Woman with Noncardiac Chest Pain |
title | Esophageal Mast Cell Infiltration in a 32-Year-Old Woman with Noncardiac Chest Pain |
title_full | Esophageal Mast Cell Infiltration in a 32-Year-Old Woman with Noncardiac Chest Pain |
title_fullStr | Esophageal Mast Cell Infiltration in a 32-Year-Old Woman with Noncardiac Chest Pain |
title_full_unstemmed | Esophageal Mast Cell Infiltration in a 32-Year-Old Woman with Noncardiac Chest Pain |
title_short | Esophageal Mast Cell Infiltration in a 32-Year-Old Woman with Noncardiac Chest Pain |
title_sort | esophageal mast cell infiltration in a 32-year-old woman with noncardiac chest pain |
topic | Brief Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694748/ https://www.ncbi.nlm.nih.gov/pubmed/26087786 http://dx.doi.org/10.5009/gnl14294 |
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