Biomechanics of vascular mechanosensation and remodeling

Flowing blood exerts a frictional force, fluid shear stress (FSS), on the endothelial cells that line the blood and lymphatic vessels. The magnitude, pulsatility, and directional characteristics of FSS are constantly sensed by the endothelium. Sustained increases or decreases in FSS induce vessel re...

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Detalles Bibliográficos
Autores principales: Baeyens, Nicolas, Schwartz, Martin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2016
Materias:
MBoC Perspective on Cell Biology and Human Health
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694763/
https://www.ncbi.nlm.nih.gov/pubmed/26715421
http://dx.doi.org/10.1091/mbc.E14-11-1522
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author Baeyens, Nicolas
Schwartz, Martin A.
author_facet Baeyens, Nicolas
Schwartz, Martin A.
author_sort Baeyens, Nicolas
collection PubMed
description Flowing blood exerts a frictional force, fluid shear stress (FSS), on the endothelial cells that line the blood and lymphatic vessels. The magnitude, pulsatility, and directional characteristics of FSS are constantly sensed by the endothelium. Sustained increases or decreases in FSS induce vessel remodeling to maintain proper perfusion of tissue. In this review, we discuss these mechanisms and their relevance to physiology and disease, and propose a model for how information from different mechanosensors might be integrated to govern remodeling.
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spelling pubmed-46947632016-03-16 Biomechanics of vascular mechanosensation and remodeling Baeyens, Nicolas Schwartz, Martin A. Mol Biol Cell MBoC Perspective on Cell Biology and Human Health Flowing blood exerts a frictional force, fluid shear stress (FSS), on the endothelial cells that line the blood and lymphatic vessels. The magnitude, pulsatility, and directional characteristics of FSS are constantly sensed by the endothelium. Sustained increases or decreases in FSS induce vessel remodeling to maintain proper perfusion of tissue. In this review, we discuss these mechanisms and their relevance to physiology and disease, and propose a model for how information from different mechanosensors might be integrated to govern remodeling. The American Society for Cell Biology 2016-01-01 /pmc/articles/PMC4694763/ /pubmed/26715421 http://dx.doi.org/10.1091/mbc.E14-11-1522 Text en © 2016 Baeyens and Schwartz. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.
spellingShingle MBoC Perspective on Cell Biology and Human Health
Baeyens, Nicolas
Schwartz, Martin A.
Biomechanics of vascular mechanosensation and remodeling
title Biomechanics of vascular mechanosensation and remodeling
title_full Biomechanics of vascular mechanosensation and remodeling
title_fullStr Biomechanics of vascular mechanosensation and remodeling
title_full_unstemmed Biomechanics of vascular mechanosensation and remodeling
title_short Biomechanics of vascular mechanosensation and remodeling
title_sort biomechanics of vascular mechanosensation and remodeling
topic MBoC Perspective on Cell Biology and Human Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694763/
https://www.ncbi.nlm.nih.gov/pubmed/26715421
http://dx.doi.org/10.1091/mbc.E14-11-1522
work_keys_str_mv AT baeyensnicolas biomechanicsofvascularmechanosensationandremodeling
AT schwartzmartina biomechanicsofvascularmechanosensationandremodeling

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