Knock out of the BASIGIN/CD147 chaperone of lactate/H+ symporters disproves its pro-tumour action via extracellular matrix metalloproteases (MMPs) induction

BASIGIN/CD147/EMMPRIN is a multifunctional transmembrane glycoprotein strongly expressed in tumours. BASIGIN controls tumour metabolism, particularly glycolysis by facilitating lactic acid export through the two monocarboxylate transporters MCT1 and hypoxia-inducible MCT4. However, before being reco...

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Detalles Bibliográficos
Autores principales: Marchiq, Ibtissam, Albrengues, Jean, Granja, Sara, Gaggioli, Cédric, Pouysségur, Jacques, Simon, Marie-Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694784/
https://www.ncbi.nlm.nih.gov/pubmed/26284589

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694784/
https://www.ncbi.nlm.nih.gov/pubmed/26284589

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