Azathioprine induction of tumors with microsatellite instability: Risk evaluation using a mouse model

Mismatch-repair (MMR)-deficient cells show increased in vitro tolerance to thiopurines because they escape apoptosis resulting from MMR-dependent signaling of drug-induced DNA damage. Prolonged treatment with immunosuppressants including azathioprine (Aza), a thiopurine prodrug, has been suggested a...

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Detalles Bibliográficos
Autores principales: Bodo, Sahra, Svrcek, Magali, Sourrouille, Isabelle, Cuillières-Dartigues, Peggy, Ledent, Tatiana, Dumont, Sylvie, Dinard, Laetitia, Lafitte, Philippe, Capel, Camille, Collura, Ada, Buhard, Olivier, Wanherdrick, Kristell, Chalastanis, Alexandra, Penard-Lacronique, Virginie, Fabiani, Bettina, Fléjou, Jean-François, Brousse, Nicole, Beaugerie, Laurent, Duval, Alex, Muleris, Martine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694807/
https://www.ncbi.nlm.nih.gov/pubmed/26327213

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