Epithelial derived CTGF promotes breast tumor progression via inducing EMT and collagen I fibers deposition

Interactions among tumor cells, stromal cells, and extracellular matrix compositions are mediated through cytokines during tumor progression. Our analysis of 132 known cytokines and growth factors in published clinical breast cohorts and our 84 patient-derived xenograft models revealed that the elev...

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Autores principales: Zhu, Xiaoping, Zhong, Jing, Zhao, Zhen, Sheng, Jianting, Wang, Jiang, Liu, Jiyong, Cui, Kemi, Chang, Jenny, Zhao, Hong, Wong, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694834/
https://www.ncbi.nlm.nih.gov/pubmed/26318291
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author Zhu, Xiaoping
Zhong, Jing
Zhao, Zhen
Sheng, Jianting
Wang, Jiang
Liu, Jiyong
Cui, Kemi
Chang, Jenny
Zhao, Hong
Wong, Stephen
author_facet Zhu, Xiaoping
Zhong, Jing
Zhao, Zhen
Sheng, Jianting
Wang, Jiang
Liu, Jiyong
Cui, Kemi
Chang, Jenny
Zhao, Hong
Wong, Stephen
author_sort Zhu, Xiaoping
collection PubMed
description Interactions among tumor cells, stromal cells, and extracellular matrix compositions are mediated through cytokines during tumor progression. Our analysis of 132 known cytokines and growth factors in published clinical breast cohorts and our 84 patient-derived xenograft models revealed that the elevated connective tissue growth factor (CTGF) in tumor epithelial cells significantly correlated with poor clinical prognosis and outcomes. CTGF was able to induce tumor cell epithelial-mesenchymal transition (EMT), and promote stroma deposition of collagen I fibers to stimulate tumor growth and metastasis. This process was mediated through CTGF-tumor necrosis factor receptor I (TNFR1)-IκB autocrine signaling. Drug treatments targeting CTGF, TNFR1, and IκB signaling each prohibited the EMT and tumor progression.
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spelling pubmed-46948342016-01-20 Epithelial derived CTGF promotes breast tumor progression via inducing EMT and collagen I fibers deposition Zhu, Xiaoping Zhong, Jing Zhao, Zhen Sheng, Jianting Wang, Jiang Liu, Jiyong Cui, Kemi Chang, Jenny Zhao, Hong Wong, Stephen Oncotarget Research Paper Interactions among tumor cells, stromal cells, and extracellular matrix compositions are mediated through cytokines during tumor progression. Our analysis of 132 known cytokines and growth factors in published clinical breast cohorts and our 84 patient-derived xenograft models revealed that the elevated connective tissue growth factor (CTGF) in tumor epithelial cells significantly correlated with poor clinical prognosis and outcomes. CTGF was able to induce tumor cell epithelial-mesenchymal transition (EMT), and promote stroma deposition of collagen I fibers to stimulate tumor growth and metastasis. This process was mediated through CTGF-tumor necrosis factor receptor I (TNFR1)-IκB autocrine signaling. Drug treatments targeting CTGF, TNFR1, and IκB signaling each prohibited the EMT and tumor progression. Impact Journals LLC 2015-07-29 /pmc/articles/PMC4694834/ /pubmed/26318291 Text en Copyright: © 2015 Zhu et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Zhu, Xiaoping
Zhong, Jing
Zhao, Zhen
Sheng, Jianting
Wang, Jiang
Liu, Jiyong
Cui, Kemi
Chang, Jenny
Zhao, Hong
Wong, Stephen
Epithelial derived CTGF promotes breast tumor progression via inducing EMT and collagen I fibers deposition
title Epithelial derived CTGF promotes breast tumor progression via inducing EMT and collagen I fibers deposition
title_full Epithelial derived CTGF promotes breast tumor progression via inducing EMT and collagen I fibers deposition
title_fullStr Epithelial derived CTGF promotes breast tumor progression via inducing EMT and collagen I fibers deposition
title_full_unstemmed Epithelial derived CTGF promotes breast tumor progression via inducing EMT and collagen I fibers deposition
title_short Epithelial derived CTGF promotes breast tumor progression via inducing EMT and collagen I fibers deposition
title_sort epithelial derived ctgf promotes breast tumor progression via inducing emt and collagen i fibers deposition
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694834/
https://www.ncbi.nlm.nih.gov/pubmed/26318291
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