Inhibition of Lon protease by triterpenoids alters mitochondria and is associated to cell death in human cancer cells

Mitochondrial Lon protease (Lon) regulates several mitochondrial functions, and is inhibited by the anticancer molecule triterpenoid 2-cyano-3, 12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO), or by its C-28 methyl ester derivative (CDDO-Me). To analyze the mechanism of action of triterpenoids, we in...

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Detalles Bibliográficos
Autores principales: Gibellini, Lara, Pinti, Marcello, Bartolomeo, Regina, De Biasi, Sara, Cormio, Antonella, Musicco, Clara, Carnevale, Gianluca, Pecorini, Simone, Nasi, Milena, De Pol, Anto, Cossarizza, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694845/
https://www.ncbi.nlm.nih.gov/pubmed/26314956

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694845/
https://www.ncbi.nlm.nih.gov/pubmed/26314956

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