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Repairing of N-mustard derivative BO-1055 induced DNA damage requires NER, HR, and MGMT-dependent DNA repair mechanisms

Alkylating agents are frequently used as first-line chemotherapeutics for various newly diagnosed cancers. Disruption of genome integrity by such agents can lead to cell lethality if DNA lesions are not removed. Several DNA repair mechanisms participate in the recovery of mono- or bi-functional DNA...

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Detalles Bibliográficos
Autores principales:	Kuo, Ching-Ying, Chou, Wen-Cheng, Wu, Chin-Chung, Wong, Teng-Song, Kakadiya, Rajesh, Lee, Te-Chang, Su, Tsann-Long, Wang, Hui-Chun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694865/ https://www.ncbi.nlm.nih.gov/pubmed/26208482

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