KMT Set7/9 affects genotoxic stress response via the Mdm2 axis

Genotoxic stress inflicted by anti-cancer drugs causes DNA breaks and genome instability. DNA double strand breaks induced by irradiation or pharmacological inhibition of Topoisomerase II activate ATM (ataxia-telangiectasia-mutated) kinase signalling pathway that in turn triggers cell cycle arrest a...

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Detalles Bibliográficos
Autores principales: Lezina, Larissa, Aksenova, Vasilisa, Fedorova, Olga, Malikova, Daria, Shuvalov, Oleg, Antonov, Alexey V., Tentler, Dmitri, Garabadgiu, Alexander V., Melino, Gerry, Barlev, Nikolai A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694870/
https://www.ncbi.nlm.nih.gov/pubmed/26317544

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