Curcumin combined with FAPαc vaccine elicits effective antitumor response by targeting indolamine-2,3-dioxygenase and inhibiting EMT induced by TNF-α in melanoma

Fibroblast activation protein α (FAPα) is a potential target for cancer therapy. However, elimination of FAPα+ fibroblasts activates secretion of IFN-γ and TNF-α. IFN-γ can in turn induce expression indolamine-2,3-dioxygenase (IDO), thereby contributing to immunosuppression, while TNF-α can induce E...

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Detalles Bibliográficos
Autores principales: Jiang, Guan-Min, Xie, Wan-Ying, Wang, Hong-Sheng, Du, Jun, Wu, Bai-Ping, Xu, Wei, Liu, Hui-Fang, Xiao, Ping, Liu, Zhi-Gang, Li, Hong-Yan, Liu, Shuang-Quan, Yin, Wen-Jun, Zhang, Qiu-Gui, Liang, Jian-Ping, Huang, Hong-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694876/
https://www.ncbi.nlm.nih.gov/pubmed/26305550

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