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Folate deficiency-triggered redox pathways confer drug resistance in hepatocellular carcinoma
Patients with hepatocellular carcinoma (HCC) are prone to folate deficiency (FD). Here we showed that, in cell line-specific manner, FD caused resistance to FD-induced oxidative stress and multi-drug resistance (MDR). This resistance was due to upregulation of glucose-regulated protein 78 (GRP78) an...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694889/ https://www.ncbi.nlm.nih.gov/pubmed/26327128 |
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author | Ho, Chun-Te Shang, Hung-Sheng Chang, Jin-Biou Liu, Jun-Jen Liu, Tsan-Zon |
author_facet | Ho, Chun-Te Shang, Hung-Sheng Chang, Jin-Biou Liu, Jun-Jen Liu, Tsan-Zon |
author_sort | Ho, Chun-Te |
collection | PubMed |
description | Patients with hepatocellular carcinoma (HCC) are prone to folate deficiency (FD). Here we showed that, in cell line-specific manner, FD caused resistance to FD-induced oxidative stress and multi-drug resistance (MDR). This resistance was due to upregulation of glucose-regulated protein 78 (GRP78) and Survivin. Using siRNA and Epigallocatechin gallate (EGCG), we found that GRP78 and Survivin cooperatively conferred MDR by decreasing FD-induced ROS generation. Our data showed that FD increases GRP78 and Survivin, which serve as ROS inhibitors, causing MDR in HCC. We suggest that folate supplementation may enhance the efficacy of chemotherapy. |
format | Online Article Text |
id | pubmed-4694889 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-46948892016-01-20 Folate deficiency-triggered redox pathways confer drug resistance in hepatocellular carcinoma Ho, Chun-Te Shang, Hung-Sheng Chang, Jin-Biou Liu, Jun-Jen Liu, Tsan-Zon Oncotarget Research Paper Patients with hepatocellular carcinoma (HCC) are prone to folate deficiency (FD). Here we showed that, in cell line-specific manner, FD caused resistance to FD-induced oxidative stress and multi-drug resistance (MDR). This resistance was due to upregulation of glucose-regulated protein 78 (GRP78) and Survivin. Using siRNA and Epigallocatechin gallate (EGCG), we found that GRP78 and Survivin cooperatively conferred MDR by decreasing FD-induced ROS generation. Our data showed that FD increases GRP78 and Survivin, which serve as ROS inhibitors, causing MDR in HCC. We suggest that folate supplementation may enhance the efficacy of chemotherapy. Impact Journals LLC 2015-06-27 /pmc/articles/PMC4694889/ /pubmed/26327128 Text en Copyright: © 2015 Ho et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Ho, Chun-Te Shang, Hung-Sheng Chang, Jin-Biou Liu, Jun-Jen Liu, Tsan-Zon Folate deficiency-triggered redox pathways confer drug resistance in hepatocellular carcinoma |
title | Folate deficiency-triggered redox pathways confer drug resistance in hepatocellular carcinoma |
title_full | Folate deficiency-triggered redox pathways confer drug resistance in hepatocellular carcinoma |
title_fullStr | Folate deficiency-triggered redox pathways confer drug resistance in hepatocellular carcinoma |
title_full_unstemmed | Folate deficiency-triggered redox pathways confer drug resistance in hepatocellular carcinoma |
title_short | Folate deficiency-triggered redox pathways confer drug resistance in hepatocellular carcinoma |
title_sort | folate deficiency-triggered redox pathways confer drug resistance in hepatocellular carcinoma |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694889/ https://www.ncbi.nlm.nih.gov/pubmed/26327128 |
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