CD44 promotes multi-drug resistance by protecting P-glycoprotein from FBXO21-mediated ubiquitination

Here we demonstrate that a ubiquitin E3-ligase, FBXO21, targets the multidrug resistance transporter, ABCB1, also known as P-glycoprotein (P-gp), for proteasomal degradation. We also show that the Ser291-phosphorylated form of the multifunctional protein and stem cell marker, CD44, inhibits FBXO21-d...

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Detalles Bibliográficos
Autores principales: Ravindranath, Abhilash K., Kaur, Swayamjot, Wernyj, Roman P., Kumaran, Muthu N., Miletti-Gonzalez, Karl E., Chan, Rigel, Lim, Elaine, Madura, Kiran, Rodriguez-Rodriguez, Lorna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694903/
https://www.ncbi.nlm.nih.gov/pubmed/26299618

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