SIRT3 inhibits prostate cancer by destabilizing oncoprotein c-MYC through regulation of the PI3K/Akt pathway

SIRT3 is involved in aging-related diseases including cancer, but its role in prostate cancer and detailed regulatory function are not known. We found that SIRT3 was moderately down-regulated in prostate carcinomas. Overexpression of SIRT3 by lentiviral transfection inhibited prostate cancer growth...

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Detalles Bibliográficos
Autores principales: Quan, Yizhou, Wang, Naitao, Chen, Qianqian, Xu, Jin, Cheng, Wei, Di, Meijuan, Xia, Weiliang, Gao, Wei-Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694917/
https://www.ncbi.nlm.nih.gov/pubmed/26317998

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