The oncolytic peptide LTX-315 kills cancer cells through Bax/Bak-regulated mitochondrial membrane permeabilization

LTX-315 has been developed as an amphipathic cationic peptide that kills cancer cells. Here, we investigated the putative involvement of mitochondria in the cytotoxic action of LTX-315. Subcellular fractionation of LTX-315-treated cells, followed by mass spectrometric quantification, revealed that t...

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Detalles Bibliográficos
Autores principales: Zhou, Heng, Forveille, Sabrina, Sauvat, Allan, Sica, Valentina, Izzo, Valentina, Durand, Sylvère, Müller, Kevin, Liu, Peng, Zitvogel, Laurence, Rekdal, Øystein, Kepp, Oliver, Kroemer, Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694939/
https://www.ncbi.nlm.nih.gov/pubmed/26378049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694939/
https://www.ncbi.nlm.nih.gov/pubmed/26378049

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