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Stromal expression of ALDH1 in human breast carcinomas indicates reduced tumor progression
Interactions between cancer cells and microenvironment are emerging issue in tumor progression. Aldehyde dehydrogenase 1 (ALDH1) is a recognized cancer stem cell marker but little is known about its role in intratumoral stroma. Therefore, we focused on ALDH1 expression in tumor-associated stroma of...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694953/ https://www.ncbi.nlm.nih.gov/pubmed/26305673 |
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author | Bednarz-Knoll, Natalia Nastały, Paulina Żaczek, Anna Stoupiec, Małgorzata Riethdorf, Sabine Wikman, Harriet Müller, Volkmar Skokowski, Jarosław Szade, Jolanta Sejda, Aleksandra Wełnicka-Jaśkiewicz, Marzena Pantel, Klaus |
author_facet | Bednarz-Knoll, Natalia Nastały, Paulina Żaczek, Anna Stoupiec, Małgorzata Riethdorf, Sabine Wikman, Harriet Müller, Volkmar Skokowski, Jarosław Szade, Jolanta Sejda, Aleksandra Wełnicka-Jaśkiewicz, Marzena Pantel, Klaus |
author_sort | Bednarz-Knoll, Natalia |
collection | PubMed |
description | Interactions between cancer cells and microenvironment are emerging issue in tumor progression. Aldehyde dehydrogenase 1 (ALDH1) is a recognized cancer stem cell marker but little is known about its role in intratumoral stroma. Therefore, we focused on ALDH1 expression in tumor-associated stroma of breast carcinomas (BrCa). Stromal and tumoral ALDH1 expression was evaluated immunohistochemically in BrCa and their lymph node metastases (LNMs), and related to clinico-pathological characteristics, patients’ outcome, presence of CD68, HLADR, retinoic acid (RA) in stroma, and selected proteins in tumor cells. ALDH1(+) stromal cells were detected in 53% of 374 BrCa and 61% of 102 LNMs. ALDH1(+) stroma in primary tumor correlated to longer disease-free (p = 0.030), metastasis-free (p = 0.024), and overall survival (p = 0.043) having an independent prognostic impact on DFS (multivariate analysis, p = 0.047). It was associated with concomitant presence of HLA-DR(+) stromal cells and RA in tumor cells (both p < 0.001), and inversely associated with vimentin expression in tumor cells (p = 0.036). ALDH1(+) stroma in LNMs correlated inversely to presence of disseminated tumor cells in patients’ bone marrow (p = 0.014) and was independent prognosticator of shorter DFS and MFS (multivariate analysis, p = 0.004 and p = 0.002, respectively). In conclusion, ALDH1 expression in tumor-associated stromal cells indicates reduced BrCa progression, possibly via RA secretion. |
format | Online Article Text |
id | pubmed-4694953 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-46949532016-01-20 Stromal expression of ALDH1 in human breast carcinomas indicates reduced tumor progression Bednarz-Knoll, Natalia Nastały, Paulina Żaczek, Anna Stoupiec, Małgorzata Riethdorf, Sabine Wikman, Harriet Müller, Volkmar Skokowski, Jarosław Szade, Jolanta Sejda, Aleksandra Wełnicka-Jaśkiewicz, Marzena Pantel, Klaus Oncotarget Research Paper: Pathology Interactions between cancer cells and microenvironment are emerging issue in tumor progression. Aldehyde dehydrogenase 1 (ALDH1) is a recognized cancer stem cell marker but little is known about its role in intratumoral stroma. Therefore, we focused on ALDH1 expression in tumor-associated stroma of breast carcinomas (BrCa). Stromal and tumoral ALDH1 expression was evaluated immunohistochemically in BrCa and their lymph node metastases (LNMs), and related to clinico-pathological characteristics, patients’ outcome, presence of CD68, HLADR, retinoic acid (RA) in stroma, and selected proteins in tumor cells. ALDH1(+) stromal cells were detected in 53% of 374 BrCa and 61% of 102 LNMs. ALDH1(+) stroma in primary tumor correlated to longer disease-free (p = 0.030), metastasis-free (p = 0.024), and overall survival (p = 0.043) having an independent prognostic impact on DFS (multivariate analysis, p = 0.047). It was associated with concomitant presence of HLA-DR(+) stromal cells and RA in tumor cells (both p < 0.001), and inversely associated with vimentin expression in tumor cells (p = 0.036). ALDH1(+) stroma in LNMs correlated inversely to presence of disseminated tumor cells in patients’ bone marrow (p = 0.014) and was independent prognosticator of shorter DFS and MFS (multivariate analysis, p = 0.004 and p = 0.002, respectively). In conclusion, ALDH1 expression in tumor-associated stromal cells indicates reduced BrCa progression, possibly via RA secretion. Impact Journals LLC 2015-07-20 /pmc/articles/PMC4694953/ /pubmed/26305673 Text en Copyright: © 2015 Bednarz-Knoll et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper: Pathology Bednarz-Knoll, Natalia Nastały, Paulina Żaczek, Anna Stoupiec, Małgorzata Riethdorf, Sabine Wikman, Harriet Müller, Volkmar Skokowski, Jarosław Szade, Jolanta Sejda, Aleksandra Wełnicka-Jaśkiewicz, Marzena Pantel, Klaus Stromal expression of ALDH1 in human breast carcinomas indicates reduced tumor progression |
title | Stromal expression of ALDH1 in human breast carcinomas indicates reduced tumor progression |
title_full | Stromal expression of ALDH1 in human breast carcinomas indicates reduced tumor progression |
title_fullStr | Stromal expression of ALDH1 in human breast carcinomas indicates reduced tumor progression |
title_full_unstemmed | Stromal expression of ALDH1 in human breast carcinomas indicates reduced tumor progression |
title_short | Stromal expression of ALDH1 in human breast carcinomas indicates reduced tumor progression |
title_sort | stromal expression of aldh1 in human breast carcinomas indicates reduced tumor progression |
topic | Research Paper: Pathology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694953/ https://www.ncbi.nlm.nih.gov/pubmed/26305673 |
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