Cargando…

Notch signaling deregulation in multiple myeloma: A rational molecular target

Despite recent therapeutic advances, multiple myeloma (MM) is still an incurable neoplasia due to intrinsic or acquired resistance to therapy. Myeloma cell localization in the bone marrow milieu allows direct interactions between tumor cells and non-tumor bone marrow cells which promote neoplastic c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Colombo, Michela, Galletti, Serena, Garavelli, Silvia, Platonova, Natalia, Paoli, Alessandro, Basile, Andrea, Taiana, Elisa, Neri, Antonino, Chiaramonte, Raffaella
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694956/ https://www.ncbi.nlm.nih.gov/pubmed/26308486

Ejemplares similares

Notch signaling drives multiple myeloma induced osteoclastogenesis
por: Colombo, Michela, et al.
Publicado: (2014)

Identification of small molecules uncoupling the Notch::Jagged interaction through an integrated high-throughput screening
por: Platonova, Natalia, et al.
Publicado: (2017)

Multiple myeloma exploits Jagged1 and Jagged2 to promote intrinsic and bone marrow-dependent drug resistance
por: Colombo, Michela, et al.
Publicado: (2020)

Multiple myeloma-derived Jagged ligands increases autocrine and paracrine interleukin-6 expression in bone marrow niche
por: Colombo, Michela, et al.
Publicado: (2016)

Re-establishing Apoptosis Competence in Bone Associated Cancers via Communicative Reprogramming Induced Through Notch Signaling Inhibition
por: Colombo, Michela, et al.
Publicado: (2019)

Cancer Cells Exploit Notch Signaling to Redefine a Supportive Cytokine Milieu
por: Colombo, Michela, et al.
Publicado: (2018)

Jagged Ligands Enhance the Pro-Angiogenic Activity of Multiple Myeloma Cells
por: Palano, Maria Teresa, et al.
Publicado: (2020)

Extracellular vesicles mediate the communication between multiple myeloma and bone marrow microenvironment in a NOTCH dependent way
por: Giannandrea, Domenica, et al.
Publicado: (2022)

Expression Pattern and Biological Significance of the lncRNA ST3GAL6-AS1 in Multiple Myeloma
por: Ronchetti, Domenica, et al.
Publicado: (2020)

The Potential of JAG Ligands as Therapeutic Targets and Predictive Biomarkers in Multiple Myeloma
por: Platonova, Natalia, et al.
Publicado: (2023)

Extracellular Vesicles Enhance Multiple Myeloma Metastatic Dissemination
por: Colombo, Michela, et al.
Publicado: (2019)

Distinct lncRNA transcriptional fingerprints characterize progressive stages of multiple myeloma
por: Ronchetti, Domenica, et al.
Publicado: (2016)

Expanding the repertoire of miRNAs and miRNA-offset RNAs expressed in multiple myeloma by small RNA deep sequencing
por: Agnelli, Luca, et al.
Publicado: (2019)

Expression levels of NONO, a nuclear protein primarily involved in paraspeckles function, are associated with several deregulated molecular pathways and poor clinical outcome in multiple myeloma
por: Ronchetti, Domenica, et al.
Publicado: (2022)

Reduction of Movement in Neurological Diseases: Effects on Neural Stem Cells Characteristics
por: Adami, Raffaella, et al.
Publicado: (2018)

P847: BIOLOGICAL AND MOLECULAR CHARACTERIZATION OF IN SILICO IDENTIFIED PUTATIVE INHIBITORS OF PARASPECKLE ASSEMBLY WITH POTENTIAL ANTI-MULTIPLE MYELOMA ACTIVITY.
por: Traini, Valentina, et al.
Publicado: (2023)

Long Non-Coding RNAs in Multiple Myeloma
por: Nobili, Lucia, et al.
Publicado: (2018)

A compendium of long non-coding RNAs transcriptional fingerprint in multiple myeloma
por: Ronchetti, Domenica, et al.
Publicado: (2018)

Activation of long non-coding RNA NEAT1 leads to survival advantage of multiple myeloma cells by supporting a positive regulatory loop with DNA repair proteins
por: Taiana, Elisa, et al.
Publicado: (2022)

Targeting the deacetylase SIRT6 unveils spliceosome deregulation as exploitable vulnerability for aggressive myeloma
por: Gelli, Elisa, et al.
Publicado: (2023)

Homotypic and Heterotypic Activation of the Notch Pathway in Multiple Myeloma–Enhanced Angiogenesis: A Novel Therapeutic Target?()
por: Saltarella, Ilaria, et al.
Publicado: (2018)

The Landscape of Signaling Pathways and Proteasome Inhibitors Combinations in Multiple Myeloma
por: Paradzik, Tina, et al.
Publicado: (2021)

DIS3 mutations in multiple myeloma impact the transcriptional signature and clinical outcome
por: Todoerti, Katia, et al.
Publicado: (2021)

Non-Coding RNAs in Multiple Myeloma Bone Disease Pathophysiology
por: Raimondi, Lavinia, et al.
Publicado: (2020)

Restoring Tissue Homeostasis at Metastatic Sites: A Focus on Extracellular Vesicles in Bone Metastasis
por: Giannandrea, Domenica, et al.
Publicado: (2021)

Deregulation of Adaptive T Cell Immunity in Multiple Myeloma: Insights Into Mechanisms and Therapeutic Opportunities
por: Leblay, Noémie, et al.
Publicado: (2020)

Genomic Instability in Multiple Myeloma: A “Non-Coding RNA” Perspective
por: Taiana, Elisa, et al.
Publicado: (2021)

Dissecting the Biological Relevance and Clinical Impact of lncRNA MIAT in Multiple Myeloma
por: Todoerti, Katia, et al.
Publicado: (2021)

P875: ACTIVATION OF LNCRNA NEAT1 LEADS TO SURVIVAL ADVANTAGE OF MULTIPLE MYELOMA CELLS BY SUPPORTING A REGULATORY LOOP WITH DNA REPAIR PROTEINS: RATIONAL BASES FOR NEAT1 THERAPEUTIC TARGETING IN THE DISEASE
por: Taiana, E., et al.
Publicado: (2022)

P849: DEPLETION OF DIS3 IN MULTIPLE MYELOMA LEADS TO PERTURBATION IN RNA METABOLISM, CELL CYCLE PROGRESSION AND MITOTIC CHECKPOINT.
por: Favasuli, V., et al.
Publicado: (2022)

Cancer-associated Notch receptor variants lead to O-fucosylation defects that deregulate Notch signaling
por: Pennarubia, Florian, et al.
Publicado: (2022)

Long non-coding RNAs in B-cell malignancies: a comprehensive overview
por: Nobili, Lucia, et al.
Publicado: (2017)

Deregulation and Targeting of TP53 Pathway in Multiple Myeloma
por: Jovanović, Katarina K., et al.
Publicado: (2019)

Single-Cell RNA Sequencing for the Detection of Clonotypic V(D)J Rearrangements in Multiple Myeloma
por: Matera, Antonio, et al.
Publicado: (2022)

Sex Steroid Regulation of Oxidative Stress in Bone Cells: An In Vitro Study
por: Sibilia, Valeria, et al.
Publicado: (2021)

An integrative genomic approach reveals coordinated expression of intronic miR-335, miR-342, and miR-561 with deregulated host genes in multiple myeloma
por: Ronchetti, Domenica, et al.
Publicado: (2008)

Epigenetic Regulation of Mitochondrial Quality Control Genes in Multiple Myeloma: A Sequenom MassARRAY Pilot Investigation on HMCLs
por: D’Aquila, Patrizia, et al.
Publicado: (2021)

Molecular Mechanisms of p53 Deregulation in Cancer: An Overview in Multiple Myeloma
por: Herrero, Ana B., et al.
Publicado: (2016)

Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia
por: Kang, Yoon-A, et al.
Publicado: (2019)

Transcriptomic Analysis in Multiple Myeloma and Primary Plasma Cell Leukemia with t(11;14) Reveals Different Expression Patterns with Biological Implications in Venetoclax Sensitivity
por: Todoerti, Katia, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_461lkltmr42st9co93qltqvvcd