A novel small-molecule IAP antagonist, AZD5582, draws Mcl-1 down-regulation for induction of apoptosis through targeting of cIAP1 and XIAP in human pancreatic cancer

Inhibitor of apoptosis proteins (IAPs) plays an important role in controlling cancer cell survival. IAPs have therefore attracted considerable attention as potential targets in anticancer therapy. In this study, we investigated the anti-tumor effect of AZD5582, a novel small-molecule IAP inhibitor,...

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Detalles Bibliográficos
Autores principales: Moon, Jai-Hee, Shin, Jae-Sik, Hong, Seung-Woo, Jung, Soo-A, Hwang, Ih-Yeon, Kim, Jeong Hee, Choi, Eun Kyoung, Ha, Seung-Hee, Kim, Jin-Sun, Kim, Kyoung-Mok, Hong, Dae-Won, Kim, Daejin, Kim, Yeong Seok, Kim, Jeong Eun, Kim, Kyu-Pyo, Hong, Yong Sang, Choi, Eun Kyung, Lee, Jung Shin, Hattersley, Maureen, Jin, Dong-Hoon, Kim, Tae Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694961/
https://www.ncbi.nlm.nih.gov/pubmed/26314849

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