Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death

The mevalonate (MVA) pathway is often dysregulated or overexpressed in many cancers suggesting tumor dependency on this classic metabolic pathway. Statins, which target the rate-limiting enzyme of this pathway, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), are promising agents currently being ev...

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Detalles Bibliográficos
Autores principales: Pandyra, Aleksandra A., Mullen, Peter J., Goard, Carolyn A., Ericson, Elke, Sharma, Piyush, Kalkat, Manpreet, Yu, Rosemary, Pong, Janice T., Brown, Kevin R., Hart, Traver, Gebbia, Marinella, Lang, Karl S., Giaever, Guri, Nislow, Corey, Moffat, Jason, Penn, Linda Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694962/
https://www.ncbi.nlm.nih.gov/pubmed/26353928

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