SIRT1 in B[a]P-induced lung tumorigenesis

Benzo[a]pyrene (B[a]P) is a carcinogen in cigarette smoke. We found that B[a]P induced SIRT1 in human bronchial epithelial BEAS-2B cell. SIRT1 was overexpressed in the lung of B[a]P-exposed mice and in human lung cancer biopsies. SIRT1 up-regulated TNF-α and β-catenin and down-regulated the membrane...

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Autores principales: Lu, Jianyi, Zhang, Min, Huang, Zhiyong, Sun, Sufang, Zhang, Yongliang, Zhang, Lei, Peng, Lirong, Ma, Ailing, Ji, Pan, Dai, Jia, Cui, Tong, Liu, Heping, Gao, Jimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694977/
https://www.ncbi.nlm.nih.gov/pubmed/26318035
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author Lu, Jianyi
Zhang, Min
Huang, Zhiyong
Sun, Sufang
Zhang, Yongliang
Zhang, Lei
Peng, Lirong
Ma, Ailing
Ji, Pan
Dai, Jia
Cui, Tong
Liu, Heping
Gao, Jimin
author_facet Lu, Jianyi
Zhang, Min
Huang, Zhiyong
Sun, Sufang
Zhang, Yongliang
Zhang, Lei
Peng, Lirong
Ma, Ailing
Ji, Pan
Dai, Jia
Cui, Tong
Liu, Heping
Gao, Jimin
author_sort Lu, Jianyi
collection PubMed
description Benzo[a]pyrene (B[a]P) is a carcinogen in cigarette smoke. We found that B[a]P induced SIRT1 in human bronchial epithelial BEAS-2B cell. SIRT1 was overexpressed in the lung of B[a]P-exposed mice and in human lung cancer biopsies. SIRT1 up-regulated TNF-α and β-catenin and down-regulated the membrane fraction of E-cadherin. In addition, SIRT1 promoted invasion, migration and tumorigenesis of BEAS-2B cells in nude mice upon B[a]P exposure. Thus, SIRT1 is involved in B[a]P-induced transformation associated with activation of the TNF-α/β-catenin axis and is as a potential therapeutic target for lung cancer.
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spelling pubmed-46949772016-01-20 SIRT1 in B[a]P-induced lung tumorigenesis Lu, Jianyi Zhang, Min Huang, Zhiyong Sun, Sufang Zhang, Yongliang Zhang, Lei Peng, Lirong Ma, Ailing Ji, Pan Dai, Jia Cui, Tong Liu, Heping Gao, Jimin Oncotarget Research Paper Benzo[a]pyrene (B[a]P) is a carcinogen in cigarette smoke. We found that B[a]P induced SIRT1 in human bronchial epithelial BEAS-2B cell. SIRT1 was overexpressed in the lung of B[a]P-exposed mice and in human lung cancer biopsies. SIRT1 up-regulated TNF-α and β-catenin and down-regulated the membrane fraction of E-cadherin. In addition, SIRT1 promoted invasion, migration and tumorigenesis of BEAS-2B cells in nude mice upon B[a]P exposure. Thus, SIRT1 is involved in B[a]P-induced transformation associated with activation of the TNF-α/β-catenin axis and is as a potential therapeutic target for lung cancer. Impact Journals LLC 2015-08-04 /pmc/articles/PMC4694977/ /pubmed/26318035 Text en Copyright: © 2015 Lu et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Lu, Jianyi
Zhang, Min
Huang, Zhiyong
Sun, Sufang
Zhang, Yongliang
Zhang, Lei
Peng, Lirong
Ma, Ailing
Ji, Pan
Dai, Jia
Cui, Tong
Liu, Heping
Gao, Jimin
SIRT1 in B[a]P-induced lung tumorigenesis
title SIRT1 in B[a]P-induced lung tumorigenesis
title_full SIRT1 in B[a]P-induced lung tumorigenesis
title_fullStr SIRT1 in B[a]P-induced lung tumorigenesis
title_full_unstemmed SIRT1 in B[a]P-induced lung tumorigenesis
title_short SIRT1 in B[a]P-induced lung tumorigenesis
title_sort sirt1 in b[a]p-induced lung tumorigenesis
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694977/
https://www.ncbi.nlm.nih.gov/pubmed/26318035
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